Investigation of Advanced Glycation End Products in Liver, Adipose, and Renal Tissue of Mice on a High-Fat Diet

Obesity is a complex condition associated with disruptions in carbohydrate, protein, and fat metabolism, linked to increased insulin resistance and glucose intolerance. High levels of Advanced Glycation End-products (AGEs) are associated with a range of chronic diseases, including kidney diseases, d...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2024-06, Vol.82 (2), p.1101-1108
Main Authors: Durak, Şermin, Yılmazer, Yasemin, Çelik, Faruk, Yeşiloğlu, Ebrar, karaköse, Dilara, Dinçol, Sena, Uçak, Sümeyye, Yaman, Mustafa, Zeybek, Ümit
Format: Article
Language:English
Subjects:
Adipose tissue
Advanced glycosylation end products
Animal tissues
Bioaccumulation
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Carbohydrate metabolism
Carbohydrates
Cardiovascular diseases
Cell Biology
Damage detection
Diabetes mellitus
Diet
Fat metabolism
Glucose metabolism
Glucose tolerance
High carbohydrate diet
High fat diet
High performance liquid chromatography
High protein diet
Insulin resistance
Kidney diseases
Kidneys
Life Sciences
Liquid chromatography
Liver
Liver diseases
Metabolic disorders
Neurodegenerative diseases
Obesity
Original Paper
Pharmacology/Toxicology
Protein turnover
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Summary:Obesity is a complex condition associated with disruptions in carbohydrate, protein, and fat metabolism, linked to increased insulin resistance and glucose intolerance. High levels of Advanced Glycation End-products (AGEs) are associated with a range of chronic diseases, including kidney diseases, diabetic complications, cardiovascular diseases, and neurodegenerative diseases. Our study aims to investigate the accumulation of AGEs in the liver, renal and adipose tissues of mice fed a high-fat diet, contributing to a deeper understanding of obesity and its related metabolic disorders. Our study consists of three different groups fed with diets containing 60% and 10% fat. The Experiment 1 group was maintained on their diet for 12 weeks, while the obese 2 and control groups continued their diets for 24 weeks. AGEs in the liver and kidney tissues obtained were measured using the High-performance liquid chromatography grade (HPLC) method. Higher accumulation of AGEs has been observed in kidney tissue compared to adipose and liver tissues ( p  
ISSN:1085-9195
1559-0283
1559-0283
DOI:10.1007/s12013-024-01260-6