Plant-derived flavonoids are a potential source of drugs for the treatment of liver fibrosis

Liver fibrosis is a dynamic pathological process that can be triggered by any chronic liver injury. If left unaddressed, it will inevitably progress to the severe outcomes of liver cirrhosis or even hepatocellular carcinoma. In the past few years, the prevalence and fatality of hepatic fibrosis have...

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Bibliographic Details
Published in:Phytotherapy research 2024-06, Vol.38 (6), p.3122-3145
Main Authors: Zhao, Bolin, Liu, Kai, Liu, Xing, Li, Qiuxia, Li, Zhibei, Xi, Jingjing, Xie, Fan, Li, Xiaofang
Format: Article
Language:English
Subjects:
Biosafety
Cell activation
Cell proliferation
Cirrhosis
Drug development
Drugs
Effectiveness
Extracellular matrix
Fibrosis
Flavonoids
Hepatocellular carcinoma
Liver
Liver cirrhosis
Oxidative stress
Pathogenesis
Stellate cells
Synthesis
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Summary:Liver fibrosis is a dynamic pathological process that can be triggered by any chronic liver injury. If left unaddressed, it will inevitably progress to the severe outcomes of liver cirrhosis or even hepatocellular carcinoma. In the past few years, the prevalence and fatality of hepatic fibrosis have been steadily rising on a global scale. As a result of its intricate pathogenesis, the quest for pharmacological interventions targeting liver fibrosis has remained a formidable challenge. Currently, no pharmaceuticals are exhibiting substantial clinical efficacy in the management of hepatic fibrosis. Hence, it is of utmost importance to expedite the development of novel therapeutics for the treatment of this condition. Various research studies have revealed the ability of different natural flavonoid compounds to alleviate or reverse hepatic fibrosis through a range of mechanisms, which are related to the regulation of liver inflammation, oxidative stress, synthesis and secretion of fibrosis-related factors, hepatic stellate cells activation, and proliferation, and extracellular matrix synthesis and degradation by these compounds. This review summarizes the progress of research on different sources of natural flavonoids with inhibitory effects on liver fibrosis over the last decades. The anti-fibrotic effects of natural flavonoids have been increasingly studied, making them a potential source of drugs for the treatment of liver fibrosis due to their good efficacy and biosafety.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.8193