Measurement of Developmental and Behavioral Concerns in Toddlers With Tuberous Sclerosis Complex

The TAND (Tuberous Sclerosis Complex [TSC]-Associated Neuropsychiatric Disorders) Checklist was developed as a clinical screener for neurodevelopmental disorders in TSC. Most studies have described patterns in older children and adults. This study sought to better understand behavioral concerns as m...

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Bibliographic Details
Published in:Pediatric neurology 2024-06, Vol.155, p.62-67
Main Authors: McDonald, Nicole M., Jacobs, Sydney, Hyde, Carly, Kasari, Connie, Jeste, Shafali S.
Format: Article
Language:English
Subjects:
Behavioral concerns
Checklist - standards
Child, Preschool
Developmental Disabilities - diagnosis
Developmental Disabilities - etiology
Female
Humans
Infant
Male
TAND
TAND Checklist
Toddlers
TSC-Associated Neuropsychiatric Disorders
Tuberous Sclerosis - complications
Tuberous Sclerosis - diagnosis
Tuberous sclerosis complex
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Summary:The TAND (Tuberous Sclerosis Complex [TSC]-Associated Neuropsychiatric Disorders) Checklist was developed as a clinical screener for neurodevelopmental disorders in TSC. Most studies have described patterns in older children and adults. This study sought to better understand behavioral concerns as measured by the TAND Checklist in young children with TSC. We examined patterns of caregiver responses to the TAND Checklist in 90 toddlers with TSC (12 to 23 months n = 60; 24 to 36 months n = 30) through data collected during baseline visits across two TSC early intervention studies. Over 90% of caregivers reported at least one behavioral concern related to TAND. The number of concerns increased with age. Delayed language was the most frequently reported concern across ages (12 to 23 months: 58.3%, 24 to 36 months: 86.7%). Questions related to behavioral concerns were largely relevant in this age range, but questions in other areas, such as neuropsychological or academic function, were not. TAND symptoms are very common in toddlers with TSC, and these symptoms may increase with age. The TAND Checklist is a useful tool for identifying behavioral concerns efficiently, but several items and sections are not suited to younger children. Results support the development of an abbreviated form of the TAND Checklist for toddlers.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2024.03.014