Age associated susceptibility to SARS-CoV-2 infection in the K18-hACE2 transgenic mouse model

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still an ongoing global health crisis. Clinical data indicate that the case fatality rate (CFR) is age dependent, with a higher CFR percentage in the elderly population. We compared the path...

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Bibliographic Details
Published in:GeroScience 2024-06, Vol.46 (3), p.2901-2913
Main Authors: Dwivedi, Varun, Shivanna, Vinay, Gautam, Shalini, Delgado, Jennifer, Hicks, Amberlee, Argonza, Marco, Meredith, Reagan, Turner, Joanne, Martinez-Sobrido, Luis, Torrelles, Jordi B., Kulkarni, Viraj
Format: Article
Language:English
Subjects:
Aged
Angiotensin-Converting Enzyme 2 - genetics
Animals
Biomedical and Life Sciences
Cell Biology
Chemokines
Coronaviruses
COVID-19
COVID-19 - immunology
COVID-19 - metabolism
Cytokines
Disease Models, Animal
Geriatrics/Gerontology
Humans
Immune response
Immunoglobulin M
Infectivity
Life Sciences
Mice
Mice, Transgenic
Molecular Medicine
Morbidity
Mortality
Original Article
Pathogenesis
Public health
SARS-CoV-2 - pathogenicity
Severe acute respiratory syndrome coronavirus 2
Transgenic mice
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Summary:Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still an ongoing global health crisis. Clinical data indicate that the case fatality rate (CFR) is age dependent, with a higher CFR percentage in the elderly population. We compared the pathogenesis of SARS-CoV-2 in young and aged K18-hACE2 transgenic mice. We evaluated morbidity, mortality, viral titers, immune responses, and histopathology in SARS-CoV-2-infected young and old K18-hACE2 transgenic mice. Within the limitation of having a low number of mice per group, our results indicate that SARS-CoV-2 infection resulted in slightly higher morbidity, mortality, and viral replication in the lungs of old mice, which was associated with an impaired IgM response and altered cytokine and chemokine profiles. Results of this study increase our understanding of SARS-CoV-2 infectivity and immuno-pathogenesis in the elderly population.
ISSN:2509-2723
2509-2715
2509-2723
DOI:10.1007/s11357-024-01102-6