Three-arm clinical trial of improved flour targeting intestinal microbiota (MALINEA)

The main objective of this project was to compare in the field conditions two strategies of re-nutrition of children with moderate acute malnutrition (MAM) aged from 6 to 24 months, targeting the microbiota in comparison with a standard regimen. A three-arm, open-label, pragmatic randomised trial wa...

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Bibliographic Details
Published in:	Maternal and child nutrition 2024-04, p.e13649-e13649
Main Authors:	Vray, Muriel, Tondeur, Laura, Hedible, Boris G, Randremanana, Rindra Vatosoa, Manirakiza, Alexandre, Lazoumar, Ramatoulaye Hamidou, Platen, Cassandre Van, Vargas, Antonio, Briend, André, Jambou, Ronan
Format:	Article
Language:	eng
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Summary:	The main objective of this project was to compare in the field conditions two strategies of re-nutrition of children with moderate acute malnutrition (MAM) aged from 6 to 24 months, targeting the microbiota in comparison with a standard regimen. A three-arm, open-label, pragmatic randomised trial was conducted in four countries (Niger, CAR, Senegal and Madagascar). Children received for 12 weeks either fortified blended flour (FBF control) = arm 1, or FBF + azithromycin (oral suspension of 20 mg/kg/day daily given with a syringe) for the first 3 days at inclusion = arm 2 or mix FBF with inulin/fructo-oligosaccharides (6 g/day if age ≥12 months and 4 g if age
ISSN:	1740-8709