Peripheral immune profile in drug-naïve dementia with Lewy bodies

Background Accumulating evidence suggests that peripheral inflammation is associated with the pathogenesis of Parkinson’s disease (PD). We examined peripheral immune profiles and their association with clinical characteristics in patients with DLB and compared these with values in patients with PD....

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Bibliographic Details
Published in:Journal of neurology 2024-07, Vol.271 (7), p.4146-4157
Main Authors: Umehara, Tadashi, Mimori, Masahiro, Kokubu, Tatsushi, Ozawa, Masakazu, Shiraishi, Tomotaka, Sato, Takeo, Onda, Asako, Matsuno, Hiromasa, Omoto, Shusaku, Sengoku, Renpei, Murakami, Hidetomo, Oka, Hisayoshi, Iguchi, Yasuyuki
Format: Article
Language:English
Subjects:
Body mass index
Cognition
Dementia disorders
Denervation
Leukocytes
Leukocytes (basophilic)
Leukocytes (neutrophilic)
Lewy bodies
Lymphocytes
Medicine
Medicine & Public Health
Movement disorders
Neostriatum
Neurodegenerative diseases
Neurology
Neuroradiology
Neurosciences
Original Communication
Parkinson's disease
Pathogenesis
Peripheral blood
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Summary:Background Accumulating evidence suggests that peripheral inflammation is associated with the pathogenesis of Parkinson’s disease (PD). We examined peripheral immune profiles and their association with clinical characteristics in patients with DLB and compared these with values in patients with PD. Methods We analyzed peripheral blood from 93 participants (drug-naïve DLB, 31; drug-naïve PD, 31; controls, 31). Absolute leukocyte counts, absolute counts of leukocyte subpopulations, and peripheral blood inflammatory indices such as neutrophil-to-lymphocyte ratio were examined. Associations with clinical characteristics, cardiac sympathetic denervation, and striatal 123 I-2-carbomethoxy-3-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( 123 I-FP-CIT) binding were also examined. Results Patients with DLB had lower absolute lymphocyte and basophil counts than did age-matched controls (both; p 
ISSN:0340-5354
1432-1459
1432-1459
DOI:10.1007/s00415-024-12336-x