A new updated prognostic index for patients with brain metastases (BMs) treated with palliative whole brain radiotherapy (WBRT) in the era of precision oncology. METASNCore project

Introduction Palliative WBRT is the main treatment for multiple BMs. Recent studies report no benefit in survival after WBRT compared to palliative supportive care in patients (pts) with poor prognosis. A new era of systemic treatment strategies based on targeted therapies are improving the prognosi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuro-oncology 2024-05, Vol.167 (3), p.407-413
Main Authors: Flores-Paco, Pablo, Vargas-Aliaga, Alicia, Guevara, María Geraldina, Lopera, Ignacio, Ruiz, Lucía Rodríguez, López-Herrero, María, Camús, Juan Adrián, López-González, Javier, Inga-Saavedra, Elizabeth, Montero, Marina, Barneto, Isidoro, Gómez-España, Mª Auxiliadora, Ruiz, Estela, Ruza, Marta, Armenta, Ana, Palacios, Amalia, De La Haba-Rodríguez, Juan R., Aranda, Enrique
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brain cancer
Brain Neoplasms - mortality
Brain Neoplasms - radiotherapy
Brain Neoplasms - secondary
Cranial Irradiation - methods
Female
Humans
Lung cancer
Male
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Middle Aged
Neurology
Oncology
Palliation
Palliative Care - methods
Precision Medicine
Prognosis
Radiation therapy
Retrospective Studies
Survival
Survival Rate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Palliative WBRT is the main treatment for multiple BMs. Recent studies report no benefit in survival after WBRT compared to palliative supportive care in patients (pts) with poor prognosis. A new era of systemic treatment strategies based on targeted therapies are improving the prognosis of patients with BMs. The purpose of this study is to develop a prognostic score in palliative pts with BMs who undergo WBRT in this new setting. Methods 239 pts with BMs who received palliative WBRT between 2013–2022 in our center were analyzed retrospectively. The score was designed according to the value of the β coefficient of each variable with statistical significance in the multivariate model using Cox regression. Once the score was established, a comparison was performed according to Kaplan–Meier and was analyzed by log-rank test. Results 149 pts (62.3%) were male and median (m) age was 60 years. 139 (58,2%) were lung cancer and 35 (14,6%) breast cancer. All patients received 30Gys in 10 sessions. m overall survival (OS) was 3,74 months (ms). 37 pts (15,5%) had a specific target mutation. We found that 62 pts were in group  7 points with mOS 2,72 ms (CI 95% 1,93–3,52) ( p  
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-024-04618-1