Matrix assisted pulsed laser evaporation of cinnamate-pullulan and tosylate-pullulan polysaccharide derivative thin films for pharmaceutical applications

We have demonstrated the successful thin film growth of two pullulan derivatives (cinnamate-pullulan and tosylate-pullulan) using matrix assisted pulsed laser evaporation (MAPLE). Our MAPLE system consisted of a KrF* laser, a vacuum chamber, and a rotating target holder cooled with liquid nitrogen....

Full description

Saved in:
Bibliographic Details
Published in:Applied surface science 2007-07, Vol.253 (19), p.7755-7760
Main Authors: Jelinek, M., Cristescu, R., Axente, E., Kocourek, T., Dybal, J., Remsa, J., Plestil, J., Mihaiescu, D., Albulescu, M., Buruiana, T., Stamatin, I., Mihailescu, I.N., Chrisey, D.B.
Format: Article
Language:English
Subjects:
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Drug delivery
Exact sciences and technology
Matrix assisted pulsed laser evaporation
Physics
Polysaccharide
Pullulan derivatives
Thin films
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have demonstrated the successful thin film growth of two pullulan derivatives (cinnamate-pullulan and tosylate-pullulan) using matrix assisted pulsed laser evaporation (MAPLE). Our MAPLE system consisted of a KrF* laser, a vacuum chamber, and a rotating target holder cooled with liquid nitrogen. Fused silica and silicon (1 1 1) wafers were used as substrates. The MAPLE-deposited thin films were characterized by transmission spectrometry, profilometry, atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy and Raman spectroscopy. The deposited layers ranged from 250 nm to 16.5 μm in thickness, depending on the laser fluence (0.065–0.5 J cm −2) and number of pulses applied for the deposition of one structure (1500–13,300). Our results confirmed that MAPLE was well-suited for the transfer of cinnamate-pullulan and tosylate-pullulan.
ISSN:0169-4332
1873-5584
DOI:10.1016/j.apsusc.2007.02.085