Plasma-induced polymerisation of hydrophilic coatings onto macroporous hydrophobic scaffolds

Macroporous poly(methyl methacrylate) scaffolds with a well-interconnected pore architecture were coated with poly(2-hydroxyethyl acrylate) following a particular protocol of plasma-induced polymerisation. Plasma-polymerised PHEA (plPHEA) was grafted onto two macroporous poly(methyl methacrylate) sc...

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Bibliographic Details
Published in:Polymer (Guilford) 2007-03, Vol.48 (7), p.2071-2078
Main Authors: Serrano Aroca, A., Monleón Pradas, M., Gómez Ribelles, J.L.
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Exact sciences and technology
Hydrogel
Medical sciences
Physicochemistry of polymers
Plasma-induced polymerisation
Polymerization
Polymers and radiations
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Water sorption
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Summary:Macroporous poly(methyl methacrylate) scaffolds with a well-interconnected pore architecture were coated with poly(2-hydroxyethyl acrylate) following a particular protocol of plasma-induced polymerisation. Plasma-polymerised PHEA (plPHEA) was grafted onto two macroporous poly(methyl methacrylate) scaffolds with varying cross-linking density showing significant differences in the interpenetration of the coating and the PMMA substrate. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) proved that the surface of the pore structure in the whole volume of the sample was coated. The stability of the plPHEA coating was studied by extraction with distilled water at different temperatures. After the extraction, these samples were observed by SEM and analysed by differential scanning calorimetry (DSC) and FTIR showing that only in very drastic conditions plPHEA suffers hydrolytic degradation.
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2007.02.017