The effect of older age on outcomes of rTMS treatment for treatment-resistant depression

Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear whether TMS is as efficacious in older adults with late-life de...

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Published in:International psychogeriatrics 2024-03, p.1-6
Main Authors: Leuchter, Michael K, Citrenbaum, Cole, Wilson, Andrew C, Tibbe, Tristan D, Jackson, Nicholas J, Krantz, David E, Wilke, Scott A, Corlier, Juliana, Strouse, Thomas B, Hoftman, Gil D, Tadayonnejad, Reza, Koek, Ralph J, Slan, Aaron R, Ginder, Nathaniel D, Distler, Margaret G, Artin, Hewa, Lee, John H, Adelekun, Adesewa E, Einstein, Evan H, Oughli, Hanadi A, Leuchter, Andrew F
Format: Article
Language:English
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Summary:Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear whether TMS is as efficacious in older adults with late-life depression (LLD) compared to younger adults with major depressive disorder (MDD). This study examined the effect of age on outcomes of rTMS treatment of adults with TRD. Self-report and observer mood ratings were measured weekly in 687 subjects ages 16-100 years undergoing rTMS treatment using the Inventory of Depressive Symptomatology 30-item Self-Report (IDS-SR), Patient Health Questionnaire 9-item (PHQ), Profile of Mood States 30-item, and Hamilton Depression Rating Scale 17-item (HDRS). All rating scales detected significant improvement with treatment; response and remission rates varied by scale but not by age (response/remission ≥ 60: 38%-57%/25%-33%;
ISSN:1041-6102
1741-203X
1741-203X
DOI:10.1017/S1041610224000462