Urinary arsenic speciation by high-performance liquid chromatography/atomic absorption spectrometry for monitoring occupational exposure to inorganic arsenic

Total urinary arsenic determinations are often used to assess occupational exposure to inorganic arsenic. Ingestion of sea food can increase the normal background levels of total arsenic in urine by up to an order of magnitude, but this arsenic has relatively little toxicity; it is tightly bound as...

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Bibliographic Details
Published in:Analytica chimica acta 1987, Vol.197, p.177-186
Main Authors: Chana, B.S., Smith, N.J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Medical sciences
Metals and various inorganic compounds
Toxicology
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Summary:Total urinary arsenic determinations are often used to assess occupational exposure to inorganic arsenic. Ingestion of sea food can increase the normal background levels of total arsenic in urine by up to an order of magnitude, but this arsenic has relatively little toxicity; it is tightly bound as arsenobetaine. The excretion of inorganic arsenic and its metabolites dimethylarsenic acid (DMA) and monomethylarsonic acid (MMA) is not influenced by the consumption of arsenic from sea food. Specific measurements of DMA, MMA and inorganic arsenic provide a more reliable indicator or exposure than total urinary arsenic levels. An automated atomic absorption method involving high-performance liquid chromatographic separation of the arsenic species and continuous hydride generation is described for the determination of arsenite, arsenate, DMA and MMA at μg As l −1 levels. The method is used to study normal urinary arsenic levels in laboratory staff and arsenic excretion by exposed workers.
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(00)84726-1