Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice

Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression...

Full description

Saved in:
Bibliographic Details
Published in:Blood 2024-06, Vol.143 (23), p.2433-2437
Main Authors: Fisher, Allison L., Phillips, Sydney, Wang, Chia-Yu, Paulo, Joao A., Xiao, Xia, Moschetta, Gillian A., Sridhar, Adhvaith, Mancias, Joseph D., Babitt, Jodie L.
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Iron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression under high-iron conditions. The master regulator of iron homeostasis, hepcidin, downregulates iron transport in high iron states and in inflammation. Hepcidin expression by the liver is mediated by the bone morphogenetic protein (BMP)–SMAD pathway. BMP6 is induced by iron, but it is not clear how liver endothelial cells acquire iron to trigger hepcidin-inducing pathways. Fisher et al present data supporting a role for ZRT/IRT-like protein 8 (ZIP8) in iron homeostasis in the setting of elevated iron, suggesting that ZIP8 mediates the uptake of non-transferrin-bound iron.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.2023023385