Association of β-globin polymorphisms and tolerance to haemonchosis in ewes and lambs of different sheep breeds

Gastrointestinal nematodes (GIN), especially Haemonchus contortus, represent a significant challenge for sheep production. Given the global concern about GIN anthelmintic resistance, alternative control methods able to reduce the dependence on these drugs are highly advisable. Since previous studies...

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Bibliographic Details
Published in:Veterinary parasitology 2024-06, Vol.328, p.110163-110163, Article 110163
Main Authors: Kapritchkoff, Rafaela Tami Ikeda, Okino, Cintia Hiromi, Niciura, Simone Cristina Méo, Bello, Hornblenda Joaquina Silva, Matos, Renata Silva, Melito, Glaucia Roberta, Bressani, Flavia Aline, Esteves, Sérgio Novita, Chagas, Ana Carolina de Souza
Format: Article
Language:English
Subjects:
Anemia
Animals
beta-Globins - genetics
Feces - parasitology
Female
Genotyping
Haemonchiasis - parasitology
Haemonchiasis - veterinary
Haemonchus - genetics
Haemonchus contortus
Haplotypes
Ovine
Parasite Egg Count - veterinary
Parasite tolerance
Polymorphism, Genetic
Resilience
Sheep
Sheep Diseases - genetics
Sheep Diseases - parasitology
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Summary:Gastrointestinal nematodes (GIN), especially Haemonchus contortus, represent a significant challenge for sheep production. Given the global concern about GIN anthelmintic resistance, alternative control methods able to reduce the dependence on these drugs are highly advisable. Since previous studies have shown that sheep carrying the Hb-A allele of β-globin are more resistant to H. contortus, this study aimed to investigate the relationship between the different haplotypes (Hb-AA, Hb-AB and Hb-BB) and phenotypes in Santa Inês (SI), Texel (TX) and White Dorper (DO) breeds infected with H. contortus. Blood samples were collected from 180 ewes and 123 lambs of the three breeds for DNA extraction followed by qPCR using a hydrolysis probe to identify the β-globin haplotypes. Phenotypic data, including fecal egg count (FEC), packed cell volume (PCV), FAMACHA score and body condition score for ewes and lambs, as well as weight gain for lambs, were collected. The genotypic frequencies of β-globin for ewes and lambs were, respectively: 21.7% and 21.4% Hb-AA, 50% and 50% Hb-AB and 28.3% and 28.6% Hb-BB in SI; 0% and 0% Hb-AA, 18.6% and 9.4% Hb-AB and 81.4% and 90.6% Hb-BB in TX; and 0% and 0% Hb-AA, 13.1% and 0% Hb-AB and 86.9% and 100% Hb-BB in DO. In ewes, mean PCV differed (p
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2024.110163