Peptide-triggered IL-12 and IFN-γ mediated immune response in CD4 + T-cells against Leishmania donovani infection

are intracellular, human blood parasites that cause visceral leishmaniasis or kala-azar. Cell-penetrating peptides (CPPs) have been shown to modulate intracellular processes and cargo delivery, whereas host defense peptides (HDPs) promote proliferation of both naïve and antigen activated CD4 T-cells...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-04, Vol.60 (30), p.4092-4095
Main Authors: Sharma, Swati, Anand, Anshul, Singh, Rajan, Singh, Rakesh K, Verma, Sandeep
Format: Article
Language:English
Subjects:
Adjuvants
Antigens
CD4-Positive T-Lymphocytes
Humans
Immune system
Immunity
Interleukin-12
Leishmania donovani
Leishmaniasis, Visceral - drug therapy
Leishmaniasis, Visceral - parasitology
Peptides
T-Lymphocytes
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Summary:are intracellular, human blood parasites that cause visceral leishmaniasis or kala-azar. Cell-penetrating peptides (CPPs) have been shown to modulate intracellular processes and cargo delivery, whereas host defense peptides (HDPs) promote proliferation of both naïve and antigen activated CD4 T-cells. We report newly designed tripeptides that were able to trigger proinflammatory cytokine (IL-12 and IFN-γ) secretion by CD4 CD44 T-cells in response to infection. These peptides can be used to induce antigen specific T responses to combat obstacles of cytotoxicity and drug resistance associated with current anti-leishmanial drugs. Furthermore, these peptides can also be used as adjuvants to develop an effective immunoprophylactic approach for immunity restoration against visceral leishmaniasis.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05946d