Deficits in olfactory system neurogenesis in neurodevelopmental disorders

Summary The role of neurogenesis in neurodevelopmental disorders (NDDs) merits much attention. The complex process by which stem cells produce daughter cells that in turn differentiate into neurons, migrate various distances, and form synaptic connections that are then refined by neuronal activity o...

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Bibliographic Details
Published in:Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2024-04, Vol.62 (2), p.e23590-n/a
Main Authors: Sweat, Sean C., Cheetham, Claire E. J.
Format: Article
Language:English
Subjects:
Animal models
Animals
Attention deficit hyperactivity disorder
Autism
Autism Spectrum Disorder
Cell differentiation
Disorders
Down's syndrome
Fragile X syndrome
Fragile X Syndrome - genetics
Humans
Hyperactivity
Intellectual disabilities
Mammals
Mice
Nervous system
Neurodevelopmental disorders
Neurodevelopmental Disorders - genetics
Neurogenesis
Neurogenesis - physiology
Neurons
Olfaction
Olfactory system
Rett syndrome
Stem cells
Synapses
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Summary:Summary The role of neurogenesis in neurodevelopmental disorders (NDDs) merits much attention. The complex process by which stem cells produce daughter cells that in turn differentiate into neurons, migrate various distances, and form synaptic connections that are then refined by neuronal activity or experience is integral to the development of the nervous system. Given the continued postnatal neurogenesis that occurs in the mammalian olfactory system, it provides an ideal model for understanding how disruptions in distinct stages of neurogenesis contribute to the pathophysiology of various NDDs. This review summarizes and discusses what is currently known about the disruption of neurogenesis within the olfactory system as it pertains to attention‐deficit/hyperactivity disorder, autism spectrum disorder, Down syndrome, Fragile X syndrome, and Rett syndrome. Studies included in this review used either human subjects, mouse models, or Drosophila models, and lay a compelling foundation for continued investigation of NDDs by utilizing the olfactory system.
ISSN:1526-954X
1526-968X
1526-968X
DOI:10.1002/dvg.23590