Deciphering the role of MicroRNAs in diabetic nephropathy: Regulatory mechanisms and molecular insights

A serious consequence of diabetes mellitus, diabetic nephropathy (DN) which causes gradual damage to the kidneys. Dietary changes, blood pressure control, glucose control, and hyperlipidemia are all important components of DN management. New research, however, points to microRNAs (miRNAs) as having...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2024-04, Vol.256, p.155237-155237, Article 155237
Main Authors: Abdelmaksoud, Nourhan M., AL-Noshokaty, Tohada M., Abdelhamid, Rehab, Abdellatif, Nourhan, Mansour, Abdallah, Mohamed, Reem, Mohamed, Asmaa Hamouda, Khalil, Nada Abd Elatif, Abdelhamid, Sara Sobhy, Mohsen, Alaa, abdelaal, Heba, Tawfik, Ahmed, Elshaer, Shereen Saeid
Format: Article
Language:English
Subjects:
Diabetes Mellitus
Diabetic Nephropathies - metabolism
Diabetic nephropathy
Humans
Kidney - metabolism
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Regulatory mechanisms
Signal Transduction - genetics
Signaling pathways
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A serious consequence of diabetes mellitus, diabetic nephropathy (DN) which causes gradual damage to the kidneys. Dietary changes, blood pressure control, glucose control, and hyperlipidemia are all important components of DN management. New research, however, points to microRNAs (miRNAs) as having a pivotal role in DN pathogenesis. Miniature non-coding RNA molecules such as miRNAs control gene expression and impact several biological processes. The canonical and non-canonical routes of miRNA biogenesis are discussed in this article. In addition, several important signaling pathways are examined in the study of miRNA regulation in DN. A deeper knowledge of these regulatory mechanisms would allow for a better understanding of the molecular basis of DN and the development of innovative therapeutic strategies. Finally, miRNAs show tremendous potential as DN diagnostic biomarkers and treatment targets, opening up promising avenues for further study and potential clinical use.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2024.155237