Antarctic fungi produce pigment with antimicrobial and antiparasitic activities

Natural pigments have received special attention from the market and industry as they could overcome the harm to health and the environmental issues caused by synthetic pigments. These pigments are commonly extracted from a wide range of organisms, and when added to products they can alter/add new p...

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Bibliographic Details
Published in:Brazilian journal of microbiology 2024-06, Vol.55 (2), p.1251-1263
Main Authors: Cavalcante, Sabrina Barros, da Silva, André Felipe, Pradi, Lucas, Lacerda, Jhuly Wellen Ferreira, Tizziani, Tiago, Sandjo, Louis Pergaud, Modesto, Lenon Romano, de Freitas, Ana Claudia Oliveira, Steindel, Mario, Stoco, Patricia Hermes, Duarte, Rubens Tadeu Delgado, Robl, Diogo
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biotechnology and Industry - Research Paper
Food Microbiology
Life Sciences
Medical Microbiology
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Mycology
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Summary:Natural pigments have received special attention from the market and industry as they could overcome the harm to health and the environmental issues caused by synthetic pigments. These pigments are commonly extracted from a wide range of organisms, and when added to products they can alter/add new physical–chemical or biological properties to them. Fungi from extreme environments showed to be a promising source in the search for biomolecules with antimicrobial and antiparasitic potential. This study aimed to isolate fungi from Antarctic soils and screen them for pigment production with antimicrobial and antiparasitic potential, together with other previously isolated strains A total of 52 fungi were isolated from soils in front of the Collins Glacier (Southeast border). Also, 106 filamentous fungi previously isolated from the Collins Glacier (West border) were screened for extracellular pigment production. Five strains were able to produce extracellular pigments and were identified by ITS sequencing as Talaromyces cnidii , Pseudogymnoascus shaanxiensis and Pseudogymnoascus sp. All Pseudogymnoascus spp. (SC04.P3, SC3.P3, SC122.P3 and ACF093) extracts were able to inhibit S. aureus ATCC6538 and two (SC12.P3, SC32.P3) presented activity against Leishmania (L.) infantum, Leishmania amazonensis and Trypanossoma cruzii . Extracts compounds characterization by UPLC-ESI-QToF analysis confirmed the presence of molecules with biological activity such as: Asterric acid, Violaceol, Mollicellin, Psegynamide A, Diorcinol, Thailandolide A. In conclusion, this work showed the potential of Antartic fungal strains from Collins Glacier for bioactive molecules production with activity against Gram positive bacteria and parasitic protozoas.
ISSN:1517-8382
1678-4405
1678-4405
DOI:10.1007/s42770-024-01308-y