Tryptophan-kynurenine metabolic pathway and daytime dysfunction in women with HIV

Sleep disturbances are prevalent in women with HIV (WWH). Tryptophan-kynurenine (T-K) pathway metabolites are associated with alterations in actigraphy derived sleep measures in WWH, although may not always correlate with functional impairment. We investigated the relationship between T-K pathway me...

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Bibliographic Details
Published in:Journal of neurovirology 2024-04, Vol.30 (2), p.122-130
Main Authors: Shorer, Eran Frank, Rubin, Leah H, French, Audrey L, Weber, Kathleen M, Daubert, Elizabeth, Yohannes, Tsion, Morack, Ralph, Clish, Clary, Bullock, Kevin, Gustafson, Deborah, Sharma, Anjali, Rogando, Andrea C, Qi, Qibin, Burgess, Helen J, Dastgheyb, Raha M
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Immunology
Infectious Diseases
Neurology
Neurosciences
Virology
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Summary:Sleep disturbances are prevalent in women with HIV (WWH). Tryptophan-kynurenine (T-K) pathway metabolites are associated with alterations in actigraphy derived sleep measures in WWH, although may not always correlate with functional impairment. We investigated the relationship between T-K pathway metabolites and self-reported daytime dysfunction in WWH and women without HIV (WWoH). 141 WWH on stable antiretroviral therapy and 140 demographically similar WWoH enrolled in the IDOze Study had targeted plasma T-K metabolites measured using liquid chromatography-tandem mass spectrometry. We utilized the daytime dysfunction component of the Pittsburgh Sleep Quality Index (PSQI) to assess functional impairment across HIV-serostatus. Lower levels of 5-hydroxytryptophan and serotonin were associated with greater daytime dysfunction in all women. In WWH, daytime dysfunction was associated with increased kynurenic acid ( R  = 0.26, p  
ISSN:1355-0284
1538-2443
1538-2443
DOI:10.1007/s13365-024-01195-x