Stromal cell‐derived factor 1 alpha (SDF‐1alfa) and cartilage oligomeric matrix protein (COMP): Two potential signature biomarkers of radiological detectable hemophilic arthropathy

Introduction Hemophilia is a rare constitutional bleeding disorder due to a deficiency in Factor VIII or Factor IX. Recurrent hemarthroses, one of the major complications of the disease, lead to hemophilic arthropathy, a disabling condition that requires early diagnosis. Traditionally, clinical exam...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2024-02, Vol.27 (2), p.e15061-n/a
Main Authors: Leuci, Alexandre, Robert, Mélanie, Josset, Laurie, Marano, Muriel, Connes, Philippe, Désage, Stéphanie, Meunier, Sandrine, Lienhart, Anne, Dargaud, Yesim
Format: Article
Language:English
Subjects:
Arthritis - complications
arthropathy
Biomarkers
bone
cartilage
Cartilage Oligomeric Matrix Protein
Chemokine CXCL12
Coagulation factors
COMP
Diagnosis
Enzyme-linked immunosorbent assay
Hemarthrosis - diagnostic imaging
Hemarthrosis - etiology
Hemophilia
Hemophilia A - complications
Hemophilia A - diagnosis
Hemophilia A - pathology
Humans
Magnetic resonance imaging
Matrix protein
Patients
Prophylaxis
Radiography
Retrospective Studies
SDF‐1α
synovium
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Summary:Introduction Hemophilia is a rare constitutional bleeding disorder due to a deficiency in Factor VIII or Factor IX. Recurrent hemarthroses, one of the major complications of the disease, lead to hemophilic arthropathy, a disabling condition that requires early diagnosis. Traditionally, clinical examination and plain film radiography have been used to diagnose hemophilic arthropathy. Magnetic resonance imaging (MRI) and ultrasound can be more useful for diagnosing soft‐tissue changes. However, but each of these methods has limitations and diagnosis of arthropathy can be delayed. Aim The aim of this project was to assess plasmatic biomolecules indicative of osteo‐cartilaginous damage in patients with hemophilia with or without known arthropathy, in order to improve the diagnosis of this major complication of the disease. Methods In this monocentric retrospective study, 40 patients with hemophilia A or B, for whom a plasma sample was available, provided informed consent for further analyses (multiplex immunoassays and ELISA) and collection of relevant clinical information in their medical files. Correlations were sought for between biomarkers of interest and the severity of joint lesions assessed according to Pettersson's radiologic score. Results Two biomarkers were identified, respectively SDF‐1α and COMP. Their plasmatic levels were significantly increased in patients with arthropathy compared to controls and patients without arthropathy. These values correlated significantly with the Pettersson score in patients under regular prophylaxis. Conclusion Two plasma biomarkers have been identified that could help assess the presence and severity of hemophilic arthropathy.
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.15061