Cyclic voltammetric response of nicotinic acid and nicotinamide on a polycrystalline gold electrode

The oxidation of nicotinic acid and nicotinamide on a polycrystalline gold electrode occurred at almost same potentials but their reduction did at different peak potentials. The redox reaction mechanisms of nicotinic acid and nicotinamide were rationalized by the formation/disappearance of the new n...

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Bibliographic Details
Published in:Electrochimica acta 2006-10, Vol.52 (1), p.361-368
Main Authors: Wang, Xiaoxia, Yang, Nianjun, Wan, Qijin
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Nicotinamide
Nicotinic acid
Pharmaceuticals
Pharmacology. Drug treatments
Polycrystalline gold electrode
Voltammetry
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Summary:The oxidation of nicotinic acid and nicotinamide on a polycrystalline gold electrode occurred at almost same potentials but their reduction did at different peak potentials. The redox reaction mechanisms of nicotinic acid and nicotinamide were rationalized by the formation/disappearance of the new nitrogen–oxygen bonds in the pyridine rings by means of cyclic voltammetry and bulk electrolysis. The anodic currents of nicotinic acid and nicotinamide were controlled by diffusion, while the cathodic ones by adsorption. The difference in the cathodic peak potentials of nicotinic acid and nicotinamide on the polycrystalline gold electrode is attributed to the effect of the electron densities of remote substituents on the pyridine rings. The cathodic peak currents at about 0.20V were linear with their concentrations in the range of 2.4mM to 2.7μM and 2.4mM to 3.3μM with detection limits of 0.27 and 0.33μM for nicotinic acid and nicotinamide, respectively. Voltammetry was then adopted for the selective monitoring the content of nicotinic acid and nicotinamide in pharmaceuticals.
ISSN:0013-4686
1873-3859
DOI:10.1016/j.electacta.2006.05.014