Intracellularly Degradable Polyelectrolyte Microcapsules

Intracellular uptake and degradation of polyelectrolyte capsules is reported in this work. Two types of intracellular degradable capsules are described: enzyme‐sensitive and hydrolysis‐ sensitive capsules (see figure). The results may be a significant step towards the biomedical application of polye...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2006-04, Vol.18 (8), p.1005-1009
Main Authors: De Geest, B. G., Vandenbroucke, R. E., Guenther, A. M., Sukhorukov, G. B., Hennink, W. E., Sanders, N. N., Demeester, J., De Smedt, S. C.
Format: Article
Language:English
Subjects:
Biomaterials
Drug delivery
Layer-by-layer assembly
Microcapsules
Polyelectrolytes
Template-directed assembly/synthesis
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Summary:Intracellular uptake and degradation of polyelectrolyte capsules is reported in this work. Two types of intracellular degradable capsules are described: enzyme‐sensitive and hydrolysis‐ sensitive capsules (see figure). The results may be a significant step towards the biomedical application of polyelectrolyte capsules.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200502128