New approaches for challenging therapeutic targets

•Many human diseases remain intractable to conventional therapeutic interventions.•There is a need for innovative treatment modalities to treat these diseases.•This report highlights key issues discussed at a workshop on novel modalities.•Novel approaches are emerging to treat previously undruggable...

Full description

Saved in:
Bibliographic Details
Published in:Drug discovery today 2024-04, Vol.29 (4), p.103942, Article 103942
Main Authors: Sharma, Karlie R., Malik, Abir, Roof, Rebecca A., Boyce, Jim P., Verma, Sharad K.
Format: Article
Language:English
Subjects:
alternative modalities
Humans
intractable disease
National Institutes of Health (U.S.)
undruggable targets
United States
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Many human diseases remain intractable to conventional therapeutic interventions.•There is a need for innovative treatment modalities to treat these diseases.•This report highlights key issues discussed at a workshop on novel modalities.•Novel approaches are emerging to treat previously undruggable targets in disease. Despite successes with new drug approvals over the past two decades through conventional drug development approaches, many human diseases remain intractable to current therapeutic interventions. Possible barriers may be that the complexity of the target, and disease biology, are impervious to such conventional drug development approaches. The US National Institutes of Health hosted a workshop with the goal of identifying challenges and opportunities with alternative modalities for developing treatments across diseases associated with historically undruggable targets. This report highlights key issues discussed during the workshop that, if addressed, could expand the pool of therapeutic approaches for treating various diseases.
ISSN:1359-6446
1878-5832
1878-5832
DOI:10.1016/j.drudis.2024.103942