Selective Construction of C–S/S–N Bonds from N‑Substituted O‑Thiocarbamates and Indoles under Transition-Metal-Free Conditions

A method for the selective construction of S–N/C­(sp2)-S bonds using N-substituted O-thiocarbamates and indoles as substrates is reported. This protocol features good atom utilization, mild conditions, short reaction time, and wide substrate scope, which can provide a convenient path for the functio...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-03, Vol.89 (6), p.4098-4112
Main Authors: Liu, Wen-Jie, Hu, Zhi-Chao, Wu, Yu-Xi, Deng, Shi-Hao, Ren, Zhi-Lin, Dong, Zhi-Bing
Format: Article
Language:English
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Summary:A method for the selective construction of S–N/C­(sp2)-S bonds using N-substituted O-thiocarbamates and indoles as substrates is reported. This protocol features good atom utilization, mild conditions, short reaction time, and wide substrate scope, which can provide a convenient path for the functionalization of indoles. In addition, the reaction could be scaled up on gram scale, showing potential application value in industry synthesis.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c02940