Adhesive capsaicin 8% patch for improved control of pain caused by chemotherapy-induced peripheral neuropathy in patients with multiple myeloma: A single-centre, seven-case series

Background Capsaicin is a highly selective agonist of the transient receptor potential vanilloid 1. The adhesive capsaicin patch provides a high capsaicin concentration (8%) directly in the painful area – its efficacy in benign peripheral neuropathic pain (diabetic neuropathy or postherpetic neuralg...

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Bibliographic Details
Published in:Journal of oncology pharmacy practice 2024-06, Vol.30 (4), p.752-758
Main Authors: Moreno-Alonso, Deborah, Llorens-Torromé, Sílvia, Corcoy de Febrer, Blanca, Amandi García, María, Serrano-Bermúdez, Gala, Trelis-Navarro, Jordi, Mayoral-Rojals, Victor, Serrano-Afonso, Ancor
Format: Article
Language:English
Subjects:
Adhesives
Aged
Analgesics
Antidepressants
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Bortezomib
Bortezomib - administration & dosage
Bortezomib - adverse effects
Bortezomib - therapeutic use
Capsaicin
Capsaicin - administration & dosage
Chemotherapy
Diabetes mellitus
Diabetic neuropathy
Female
Humans
Male
Middle Aged
Morphine
Multiple myeloma
Multiple Myeloma - drug therapy
Neuralgia
Neuralgia - chemically induced
Neuralgia - drug therapy
Pain
Pain Measurement
Peripheral Nervous System Diseases - chemically induced
Peripheral Nervous System Diseases - drug therapy
Peripheral neuropathy
Retrospective Studies
Thalidomide
Thalidomide - administration & dosage
Thalidomide - adverse effects
Thalidomide - therapeutic use
Transdermal Patch
Transient receptor potential proteins
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Summary:Background Capsaicin is a highly selective agonist of the transient receptor potential vanilloid 1. The adhesive capsaicin patch provides a high capsaicin concentration (8%) directly in the painful area – its efficacy in benign peripheral neuropathic pain (diabetic neuropathy or postherpetic neuralgia) has recently been described in the literature. However, there is scant evidence of its efficacy in chemotherapy-induced peripheral neuropathy (CIPN). This is a concern for patients with multiple myeloma, who suffer from peripheral neuropathic pain induced by first-line treatments (bortezomib or thalidomide). Aim To describe improved control of CIPN in patients with multiple myeloma using adhesive capsaicin 8% patch. Methods We opted for a retrospective observational case series. Between October 2017 and October 2020, we collected clinical data from adult multiple myeloma patients affected by CIPN who were administered the capsaicin 8% patch in our palliative care outpatient clinic. We compiled Numerical Pain Rating Scale (NPRS) scores, patients’ medication needs and performance status before and after patch application. Results Two women and five men with an average age of 62.85 years received bortezomib. Two patients (28.57% of the sample) also received thalidomide. The average NPRS score before patch application was 6.42/10. Five of the seven patients (71.42%) received a mean daily oral morphine dose of 52.85 mg/day, five (71.42%) received gabapentinoids and one (14.28%) received antidepressants. The average NPRS score decreased to 4/10 seven days after patch application, while the mean daily oral morphine dose remained stable. Performance status improved slightly in two patients (28.57%) and remained stable in the rest. One patient (14.28%) required an extra analgesic dose during patch application. Conclusions Capsaicin 8% patch application appears to reduce pain intensity in patients with multiple myeloma suffering from CIPN.
ISSN:1078-1552
1477-092X
1477-092X
DOI:10.1177/10781552241230887