A systematic review and meta‐analysis of serum lipid concentrations in people with Down syndrome

Background Down syndrome (DS) is the most prevalent chromosomal disorder, being the leading cause of intellectual disability. The increased life expectancy of individuals with DS has led to a shift in the incidence of non‐communicable chronic diseases, resulting in new concerns, particularly cardiov...

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Bibliographic Details
Published in:Journal of intellectual disability research 2024-06, Vol.68 (6), p.553-563
Main Authors: Gastelum Guerrero, Carolina, Cháidez Fernández, Yuridia Lizet, Magaña Ordorica, Dalia, Berger, Heidi, Vazquez Landrove, Marilyn, Guadrón Llanos, Alma, Angulo Rojo, Carla, Magaña Gómez, Javier
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alzheimer's disease
Analysis
Blood
Cardiovascular diseases
Cholesterol
Cholesterol - blood
Chromosomes
Chronic illnesses
Down syndrome
Down Syndrome - blood
Down Syndrome - epidemiology
Dyslipidaemia
High‐density lipoprotein
Humans
Intellectual disabilities
Learning disabled people
Life expectancy
Lipid profile
Lipids
Lipids - blood
Medical libraries
Meta-analysis
Serum
Systematic review
Triglycerides
Triglycerides - blood
Young Adult
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Summary:Background Down syndrome (DS) is the most prevalent chromosomal disorder, being the leading cause of intellectual disability. The increased life expectancy of individuals with DS has led to a shift in the incidence of non‐communicable chronic diseases, resulting in new concerns, particularly cardiovascular disease (CVD) and Alzheimer's disease. This study aimed to analyse the blood lipid profile of a large DS cohort to establish a baseline for evaluating health risk parameters. Methods A comprehensive literature search was conducted on PubMed and Virtual Health Library databases to identify original articles published before July 2022. Selected studies were included in the meta‐analysis. Results Fifteen studies reporting serum lipid levels in individuals with DS were incorporated into the analysis. The meta‐analysis used the means and standard deviations extracted from the selected studies. The analysis encompassed 671 participants in the DS group and 898 euploid controls. The results indicated significant differences in total cholesterol [C] (mean difference [MD]: −3.34; CI: 95%: −4.94 to −1.73; P 
ISSN:0964-2633
1365-2788
DOI:10.1111/jir.13128