Rare Co-occurrence of Spinal Cord Hemorrhage from Radiation-induced Cavernous Hemangioma and Classical Hodgkin Lymphoma Post-transplant Lymphoproliferative Disorder

Post-transplant lymphoproliferative disorders (PTLDs) are lymphoproliferative diseases that occur after solid organ transplantation or hematopoietic stem cell transplantation (HSCT). The development of PTLD is often associated with reactivation of Epstein-Barr virus (EBV). A 26-year-old woman with a...

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Published in:Internal Medicine 2024, pp.2898-23
Main Authors: Shimizu, Takahiro, Nagashima, Yu, Matsukawa, Takashi, Mitsutake, Akihiko, Kawai, Mizuho, Horiuchi, Yurino, Yokoyama, Keishi, Takaoka, Kensuke, Kurihara, Yuya, Toyama, Kazuhiro, Sakuishi, Kaori, Kurokawa, Mineo, Toda, Tatsushi
Format: Article
Language:English
Subjects:
Epstein-Barr virus
Post-transplant lymphoproliferative disorders
radiation-induced cavernous hemangioma
spinal cord hemorrhage
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Summary:Post-transplant lymphoproliferative disorders (PTLDs) are lymphoproliferative diseases that occur after solid organ transplantation or hematopoietic stem cell transplantation (HSCT). The development of PTLD is often associated with reactivation of Epstein-Barr virus (EBV). A 26-year-old woman with a history of HSCT and total-body irradiation developed spinal cord hemorrhage from a radiation-induced cavernous hemangioma (RICH) shortly after the development of classical Hodgkin lymphoma PTLD with EBV reactivation. Although little is known about the factors leading to hemorrhagic events from spinal cord RICH, we suspect that EBV reactivation may have been a factor contributing to the hemorrhage in the present case.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2898-23