Analysis of atorvastatin in environmental waters: Validation of an electrochemical molecularly imprinted polymer sensor with application of life cycle assessment

The widespread presence of pharmaceuticals in wastewater effluents after treatment stands as a significant challenge faced in the field of wastewater management and public health. Governments and the scientific community have worked to meet this urgent need for effective solutions. Nevertheless, the...

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Bibliographic Details
Published in:The Science of the total environment 2024-04, Vol.921, p.171169-171169, Article 171169
Main Authors: Rebelo, Patrícia, Seguro, Isabel, Surra, Elena, Paíga, Paula, Pacheco, João G., Delerue-Matos, Cristina
Format: Article
Language:English
Subjects:
Animals
Atorvastatin
Electrochemical sensor
Electrochemical Techniques - methods
Life Cycle Stages
Limit of Detection
Molecular Imprinting - methods
Molecularly Imprinted Polymers
Pharmaceutical Preparations
Pharmaceuticals
Sustainable monitoring
Tandem Mass Spectrometry
Wastewater
Wastewater effluents
Water
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Summary:The widespread presence of pharmaceuticals in wastewater effluents after treatment stands as a significant challenge faced in the field of wastewater management and public health. Governments and the scientific community have worked to meet this urgent need for effective solutions. Nevertheless, the development of detection strategies for pharmaceutical monitorization capable of delivering rapid, on-site, and sensitive responses remains an ongoing necessity. In this work, the performance of a previously developed molecularly imprinted polymer (MIP) based electrochemical sensor for detecting atorvastatin (ATV) in wastewater effluents and surface waters is presented. A simple preconcentration method followed by electrochemical measurements by differential pulse voltammetry (DPV) in 0.1 M phosphate buffer (pH = 7), was implemented. The analytical results were validated with those obtained on a set of 16 water samples by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). Additionally, a life cycle assessment (LCA) was conducted to compare the environmental impact of both methodologies. The results obtained demonstrated that ATV detection using MIP-sensor was reliable when compared to the results found by UHPLC-MS/MS presenting a robust linear correlation coefficient of 0.843. The LCA results show that the novel MIP-sensor technique has lower associated environmental impacts than UHPLC-MS/MS, when the current analytical protocol for pharmaceuticals detection is applied. These findings highlight the potential of the developed MIP-sensor as an eco-friendly analytical tool for routine analysis and point-of-care monitoring of ATV in WWTP wastewater and surface water samples. [Display omitted] •The sensor effectively monitored both WWTPs effluents and surface water samples.•The developed MIP-sensor provides a simple, low cost and rapid analysis.•Selective MIP performance for ATV detection was compared with UHPLC-MS/MS.•Enhancing sustainability to ATV monitorization with electrochemical MIP-sensor•Life Cycle Assessment for comparison of MIP-sensor and UHPLC-MS/MS techniques
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2024.171169