Parent–child interaction related to brain functional alterations and development outcomes in autism spectrum disorder: A study based on resting state-fMRI

Limited study has investigated the influence of parent–child interaction on brain functional alterations and development outcomes of autism spectrum disorder (ASD) children. This pilot study aimed to explore the relationship between parent–child interaction, brain functional activities and developme...

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Published in:Research in developmental disabilities 2024-04, Vol.147, p.104701-104701, Article 104701
Main Authors: Xue, Yang, Dong, Han-yu, Feng, Jun-yan, Bai, Miao-shui, Li, Dan, Yang, Hong, Jia, Fei-yong
Format: Article
Language:English
Subjects:
Amplitude of low-frequency fluctuations
Autism
Autism Spectrum Disorder - diagnostic imaging
Brain - diagnostic imaging
Brain Mapping - methods
Child
Child, Preschool
Developmental quotient
Humans
Magnetic Resonance Imaging - methods
Parent-child interaction
Pilot Projects
Regional homogeneity
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Summary:Limited study has investigated the influence of parent–child interaction on brain functional alterations and development outcomes of autism spectrum disorder (ASD) children. This pilot study aimed to explore the relationship between parent–child interaction, brain functional activities and development outcomes of ASD children. and Procedures: 653 ASD with an average age of 41.06 ± 10.88 months and 102 typically developmental (TD) children with an average age of 44.35 ± 18.39 months were enrolled in this study, of whom 155 ASD completed brain rs-fMRI scans. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) measured using resting-state functional magnetic resonance imaging (rs-fMRI) data reflect local brain function. The parent-child interaction was assessed by the Chinese Parent–child Interaction Scale (CPCIS). Childhood Autism Rating Scale (CARS) and developmental quotient (DQ) indicated development outcomes. Total CPCIS score was negatively correlated with CARS total score, and positively correlated with DQ. The frequency of parent–child interaction was negatively correlated with ALFF values in the left median cingulate and paracingulate gyri (DCG.L) and ReHo values in the right superior frontal gyrus, medial (SFGmed.R)(P 
ISSN:0891-4222
1873-3379
DOI:10.1016/j.ridd.2024.104701