Comparative analysis of electrochemical and optical sensors for detection of chronic wounds biomarkers: A review

Chronic wounds (CW) present a significant healthcare challenge due to their prolonged healing time and associated complications. To effectively treat these wounds and prevent further deterioration, monitoring their healing progress is crucial. Traditional wound assessment methods relying on visual i...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2024-05, Vol.251, p.116095-116095, Article 116095
Main Authors: Mota, Fátima A.R., Passos, Marieta L.C., Santos, João L.M., Saraiva, M.Lúcia M.F.S.
Format: Article
Language:English
Subjects:
Bioensors
Biomarkers
Biomarkers - analysis
Biosensing Techniques
Chronic wounds
Delivery of Health Care
Electrochemical
Humans
Optical
Wound Healing
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Summary:Chronic wounds (CW) present a significant healthcare challenge due to their prolonged healing time and associated complications. To effectively treat these wounds and prevent further deterioration, monitoring their healing progress is crucial. Traditional wound assessment methods relying on visual inspection and subjective evaluation are prone to inter-observer variability. Biomarkers play a critical role in objectively evaluating wound status and predicting healing outcomes, providing quantitative measures of wound healing progress, inflammation, infection, and tissue regeneration. Recent attention has been devoted to identifying and validating CW biomarkers. Various studies have investigated potential biomarkers, including growth factors, cytokines, proteases, and extracellular matrix components, shedding light on the complex molecular and cellular processes within CW. This knowledge enables a more targeted and personalized approach to wound management. Accurate and sensitive techniques are necessary for detecting CW biomarkers. Thus, this review compares and discusses the use of electrochemical and optical sensors for biomarker determination. The advantages and disadvantages of these sensors are highlighted. Differences in detection capabilities and characteristics such as non-invasiveness, portability, high sensitivity, specificity, simplicity, cost-effectiveness, compatibility with point-of-care applications, and real-time monitoring of wound biomarkers will be pointed out and compared. In summary, this work provides an overview of CW, explores the emerging field of CW biomarkers, and discusses methods for detecting these biomarkers, with a specific focus on optical and electrochemical sensors. The potential of further research and development in this field for advancing wound care and improving patient outcomes will also be noted. [Display omitted] •Chronic wounds affect millions worldwide and are a significant public health concern.•To not to progress to more serious states, early detection is important.•Chronic wounds biomarkers can be used for early detection.•Optical and electrochemical sensors have shown very promising results.•These sensors demonstrated advantages that are not found in routinely used methods.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2024.116095