Camellia oil exhibits anti‐fatigue property by modulating antioxidant capacity, muscle fiber, and gut microbial composition in mice

Camellia seed oil (CO) has high nutritional value and multiple bioactivities. However, the specific anti‐fatigue characteristics and the implied mechanism of CO have not yet been fully elucidated. Throughout this investigation, male C57BL/6J mice, aged 8 weeks, underwent exhaustive exercise with or...

Full description

Saved in:
Bibliographic Details
Published in:Journal of food science 2024-04, Vol.89 (4), p.2465-2481
Main Authors: Huang, Shiying, Sun, Huiyu, Lin, Dai, Huang, Xinjue, Chen, Ruiran, Li, Minli, Huang, Jialing, Guo, Fuchuan
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Animals
Antioxidants
Antioxidants - pharmacology
anti‐fatigue
ATP
Bacteroidetes
Barriers
Camellia
camellia oil
Composition
Dysbacteriosis
Fatigue
Fatigue - drug therapy
Fatigue - metabolism
Firmicutes
Functional foods & nutraceuticals
Gastrointestinal Microbiome - genetics
Gene expression
Glycogen
Glycogens
gut microbiota
Lactic acid
Male
Mice
Mice, Inbred C57BL
Microorganisms
mRNA
Muscle Fibers, Skeletal
Muscles
Muscular fatigue
myofiber
NRF2 protein
Nutritive value
Oils & fats
Oilseeds
Oxidative stress
Physical training
Plant Oils - pharmacology
Urea
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Camellia seed oil (CO) has high nutritional value and multiple bioactivities. However, the specific anti‐fatigue characteristics and the implied mechanism of CO have not yet been fully elucidated. Throughout this investigation, male C57BL/6J mice, aged 8 weeks, underwent exhaustive exercise with or without CO pretreatment (2, 4, and 6 mL/kg BW) for 28 days. CO could extend the rota‐rod and running time, reduce blood urea nitrogen levels and serum lactic acid, and increase muscle and hepatic glycogen, adenosine triphosphate, and anti‐oxidative indicators. Additionally, CO could upregulate the mRNA and Nrf2 protein expression levels, as well as enhance the levels of its downstream antioxidant enzymes and induce the myofiber‐type transformation from fast to slow and attenuate the gut mechanical barrier. Moreover, CO could ameliorate gut dysbiosis by reducing Firmicutes to Bacteroidetes ratio at the phylum level, increasing the percentage of Alistipes, Alloprevotella, Lactobacillus, and Muribaculaceae, and decreasing the proportion of Dubosiella at the genus level. In addition, specific bacterial taxa, which were altered by CO, showed a significant correlation with partial fatigue‐related parameters. These findings suggest that CO may alleviate fatigue by regulating antioxidant capacity, muscle fiber transformation, gut mechanical barrier, and gut microbial composition in mice. Practical Application Our study revealed that camellia seed oil (CO) could ameliorate exercise‐induced fatigue in mice by modulating antioxidant capacity, muscle fiber, and gut microbial composition in mice. Our results promote the application of CO as an anti‐fatigue functional food that targets oxidative stress, myofiber‐type transformation, and microbial community.
ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.16983