Elevated phase amplitude coupling as a depression biomarker in epilepsy

•A broad theta-alpha-beta phase (5–25 Hz)-gamma amplitude (80–100 Hz) elevated Phase Amplitude Coupling signal differentiated depressed from non-depressed epilepsy patients.•Phase Amplitude Coupling may be an anatomically specific, putative biomarker candidate of active sustained depressive symptoms...

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Bibliographic Details
Published in:Epilepsy & behavior 2024-03, Vol.152, p.109659-109659, Article 109659
Main Authors: Young, James J., Chan, Andy Ho Wing, Jette, Nathalie, Bender, Heidi A., Saad, Adam E., Saez, Ignacio, Panov, Fedor, Ghatan, Saadi, Yoo, Ji Yeoun, Singh, Anuradha, Fields, Madeline C., Marcuse, Lara V., Mayberg, Helen S.
Format: Article
Language:English
Subjects:
Adult
Brain
Brain Waves - physiology
Comorbid Depression
Depression
Depression - diagnosis
Depression - etiology
Electroencephalography
Epilepsy
Epilepsy - complications
Epilepsy - diagnosis
Humans
Intracranial EEG
Phase Amplitude Coupling
Prefrontal Cortex
Spectral Power
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Summary:•A broad theta-alpha-beta phase (5–25 Hz)-gamma amplitude (80–100 Hz) elevated Phase Amplitude Coupling signal differentiated depressed from non-depressed epilepsy patients.•Phase Amplitude Coupling may be an anatomically specific, putative biomarker candidate of active sustained depressive symptoms in patients with epilepsy.•Phase Amplitude Coupling signal differed in brain regions between neocortical epilepsy and mesial temporal epilepsy patients. Depression is prevalent in epilepsy patients and their intracranial brain activity recordings can be used to determine the types of brain activity that are associated with comorbid depression. We performed case-control comparison of spectral power and phase amplitude coupling (PAC) in 34 invasively monitored drug resistant epilepsy patients’ brain recordings. The values of spectral power and PAC for one-minute segments out of every hour in a patient’s study were correlated with pre-operative assessment of depressive symptoms by Beck Depression Inventory-II (BDI). We identified an elevated PAC signal (theta-alpha–beta phase (5–25 Hz)/gamma frequency (80–100 Hz) band) that is present in high BDI scores but not low BDI scores adult epilepsy patients in brain regions implicated in primary depression, including anterior cingulate cortex, amygdala and orbitofrontal cortex. Our results showed the application of PAC as a network-specific, electrophysiologic biomarker candidate for comorbid depression and its potential as treatment target for neuromodulation.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2024.109659