The value of calcofluor white in the diagnosis of invasive fungal diseases

To evaluate the value of calcofluor white in the diagnosis of invasive fungal disease (IFD). A total of 84 patients with possible pulmonary fungal infection who underwent bronchoscopy with bronchoalveolar lavage fluid (BALF) were included. All BALF specimens were subjected to Calcofluor white (CFW),...

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Published in:Diagnostic microbiology and infectious disease 2024-04, Vol.108 (4), p.116186-116186, Article 116186
Main Authors: Zhang, Shuya, Chen, Zhongbo, Deng, Zaichun, Fu, Panfeng, Yu, Yiming, Zhuang, Qidong, Yu, Xuechan, Chen, Hui, Li, Anqi, Zheng, Lin
Format: Article
Language:English
Subjects:
Benzenesulfonates
Bronchoalveolar Lavage Fluid
Calcofluor white
Diagnosis
Gentian Violet
Humans
Invasive fungal disease
Mycoses - diagnosis
Phenazines
Sensitivity and Specificity
Staining and Labeling
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Summary:To evaluate the value of calcofluor white in the diagnosis of invasive fungal disease (IFD). A total of 84 patients with possible pulmonary fungal infection who underwent bronchoscopy with bronchoalveolar lavage fluid (BALF) were included. All BALF specimens were subjected to Calcofluor white (CFW), potassium hydroxide (KOH) and Gram stains. CFW has the most sensitivity than KOH and Gram staining. The specificity of CFW was 92.00 %, which was lower than that of Gram staining. The PPVs for CFW, KOH and Gram staining were 94.44 %, 84.62 % and 80.00 % respectively. The NPVs for CFW, KOH and Gram staining was 47.92 %, 32.39 % and 30.38 % respectively. The AUCs of these three methods were 0.748, 0.550 and 0.510 respectively. CFW is superior to KOH and Gram staining in the diagnosis of invasive fungal diseases.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2024.116186