Changes of long-term survival of resection and liver transplantation in hepatocellular carcinoma throughout the years: A meta-analysis

Hepatocellular Carcinoma (HCC) still is one of the most detrimental malignant diseases in the world. As two curative surgical therapies exist, the discussion whether to opt for liver resection (LR) or transplantation (LT) is ongoing, especially as novel techniques to improve outcome have emerged for...

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Published in:European journal of surgical oncology 2024-03, Vol.50 (3), p.107952-107952, Article 107952
Main Authors: Drefs, Moritz, Schoenberg, Markus B., Börner, Nikolaus, Koliogiannis, Dionysios, Koch, Dominik T., Schirren, Malte J., Andrassy, Joachim, Bazhin, Alexandr V., Werner, Jens, Guba, Markus O.
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular
HCC
Hepatectomy - methods
Hepatocellular carcinoma
Humans
Liver Neoplasms - therapy
Liver resection
Liver transplantation
Liver Transplantation - methods
Living-donor liver transplantation
meta-Analysis
Neoplasm Recurrence, Local - surgery
Retrospective Studies
Survival Rate
Treatment Outcome
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Summary:Hepatocellular Carcinoma (HCC) still is one of the most detrimental malignant diseases in the world. As two curative surgical therapies exist, the discussion whether to opt for liver resection (LR) or transplantation (LT) is ongoing, especially as novel techniques to improve outcome have emerged for both. The aim of the study was to investigate how the utilization and outcome of the respective modalities changed through time. We searched Medline and PubMed for relevant publications comparing LT and LR in HCC patients during the time period from 1990 to 2022, prior to March 31, 2023. A total of 63 studies involving 19,804 patients – of whom 8178 patients received a liver graft and 11,626 underwent partial hepatectomy - were included in this meta-analysis. LT is associated with significantly better 5-year overall survival (OS) (64.83%) and recurrence-free survival (RFS) (70.20%) than LR (OS: 50.83%, OR: 1.79, p 
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2024.107952