Vitamin D deficiency promotes intracranial aneurysm rupture

Intracranial aneurysm rupture causes severe disability and high mortality. Epidemiological studies show a strong association between decreased vitamin D levels and an increase in aneurysm rupture. However, the causality and mechanism remain largely unknown. In this study, we tested whether vitamin D...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2024-07, Vol.44 (7), p.1174-1183
Main Authors: Kimura, Tetsuro, Rahmani, Redi, Miyamoto, Takeshi, Kamio, Yoshinobu, Kudo, Daisuke, Sato, Hiroki, Ikedo, Taichi, Baranoski, Jacob F, Uchikawa, Hiroki, Ai, Jinglu, Lawton, Michael T, Hashimoto, Tomoki
Format: Article
Language:English
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Summary:Intracranial aneurysm rupture causes severe disability and high mortality. Epidemiological studies show a strong association between decreased vitamin D levels and an increase in aneurysm rupture. However, the causality and mechanism remain largely unknown. In this study, we tested whether vitamin D deficiency promotes aneurysm rupture and examined the underlying mechanism for the protective role of vitamin D against the development of aneurysm rupture utilizing a mouse model of intracranial aneurysm. Mice consuming a vitamin D-deficient diet had a higher rupture rate than mice with a regular diet. Vitamin D deficiency increased proinflammatory cytokines in the cerebral arteries. Concurrently, vitamin D receptor knockout mice had a higher rupture rate than the corresponding wild-type littermates. The vitamin D receptors on endothelial and vascular smooth muscle cells, but not on hematopoietic cells, mediated the effect of aneurysm rupture. Our results establish that vitamin D protects against the development of aneurysmal rupture through the vitamin D receptors on vascular endothelial and smooth muscle cells. Vitamin D supplementation may be a viable pharmacologic therapy for preventing aneurysm rupture.
ISSN:0271-678X
1559-7016
DOI:10.1177/0271678X241226750