The polymorphism T1470A of the SLC16A1 gene is associated with the lactate and ventilatory thresholds but not with fat oxidation capacity in young men

Purpose To examine the association of the single nucleotide polymorphism A1470T in the SLC16A1 gene with blood lactate accumulation during a graded exercise test and its associated metaboreflex. Methods Forty-six Latin-American men (Age: 27 ± 6 years; Body fat: 17.5 ± 4.7%) performed a graded exerci...

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Bibliographic Details
Published in:European journal of applied physiology 2024-06, Vol.124 (6), p.1835-1843
Main Authors: Chávez-Guevara, Isaac A., González-Rodríguez, Everardo, Moreno-Brito, Verónica, Pérez-León, Jorge A., Amaro-Gahete, Francisco J., Trejo-Trejo, Marina, Ramos-Jiménez, Arnulfo
Format: Article
Language:English
Subjects:
Adult
Alleles
Anaerobic Threshold - genetics
Anaerobic Threshold - physiology
Biomedical and Life Sciences
Biomedicine
Body composition
Body fat
Calorimetry
Cardiorespiratory fitness
Exercise - physiology
Exercise Test
Gene frequency
Gene polymorphism
Genotype
Genotyping
Human Physiology
Humans
Lactic acid
Lactic Acid - blood
Lipid Metabolism - genetics
Lipid Metabolism - physiology
Male
Monocarboxylic Acid Transporters - genetics
Monocarboxylic Acid Transporters - metabolism
Occupational Medicine/Industrial Medicine
Original Article
Oxidation
Oxidation-Reduction
Oxygen Consumption - genetics
Oxygen Consumption - physiology
Peripheral blood
Physical fitness
Polymorphism
Polymorphism, Single Nucleotide
Single-nucleotide polymorphism
Sports Medicine
Symporters - genetics
Ventilatory behavior
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Summary:Purpose To examine the association of the single nucleotide polymorphism A1470T in the SLC16A1 gene with blood lactate accumulation during a graded exercise test and its associated metaboreflex. Methods Forty-six Latin-American men (Age: 27 ± 6 years; Body fat: 17.5 ± 4.7%) performed a graded exercise test on a treadmill for the assessment of maximal oxygen uptake (VO 2max ), lactate threshold (LT), ventilatory threshold (VT) and the exercise intensity corresponding to maximal fat oxidation rate (FATmax), via capillary blood samples and indirect calorimetry. Genomic DNA was extracted from a peripheral blood sample. Genotyping assay was carried out by real-time polymerase chain reaction to identify the A1470T polymorphism (rs1049434). Results Genotypes distribution were in Hardy–Weinberg equilibrium ( X 2  = 5.6, p  > 0.05), observing allele frequencies of 0.47 and 0.53 for the A and T alleles, respectively. No difference in VO 2max , body composition nor FATmax were observed across genotypes, whereas carriers of the TT genotype showed a higher LT (24.5 ± 2.2 vs. 15.6 ± 1.7 mL kg −1  min −1 , p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-023-05407-w