Dendrobium officinale flowers' topical extracts improve skin oxidative stress and aging

Background Dendrobium officinale flowers (DOF) have the effects of antiaging and nourishing yin, but it lacks pharmacological research on skin aging. Objective Confirming the role of DOF in delaying skin aging based on the “in vitro animal–human” model. Methods In this experiment, three kinds of fre...

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Bibliographic Details
Published in:Journal of cosmetic dermatology 2024-05, Vol.23 (5), p.1891-1904
Main Authors: He, Xing‐Li‐Shang, Wang, Ning, Teng, Xi, Wang, Nan‐Nan, Xie, Zhi‐Yi, Dong, Ying‐Jie, Lin, Min‐Qiu, Zhang, Ze‐Hua, Rong, Mei, Chen, Yi‐Gong, Li, Bo, Lv, Gui‐Yuan, Chen, Su‐Hong
Format: Article
Language:English
Subjects:
Animals
antioxidant capacity
Antioxidants - administration & dosage
Antioxidants - pharmacology
Dendrobium - chemistry
Dendrobium officinale flower
Female
Flowers - chemistry
Humans
in vitro animal–human model
Male
Mice
Oxidative Stress - drug effects
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Skin - drug effects
Skin - metabolism
skin aging
Skin Aging - drug effects
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Summary:Background Dendrobium officinale flowers (DOF) have the effects of antiaging and nourishing yin, but it lacks pharmacological research on skin aging. Objective Confirming the role of DOF in delaying skin aging based on the “in vitro animal–human” model. Methods In this experiment, three kinds of free radical scavenging experiments in vitro, D‐galactose‐induced aging mouse model, and human antiaging efficacy test were used to test whether DOF can improve skin aging through anti‐oxidation. Results In vitro experiment shows that DOF has certain scavenging effect on 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical, hydroxyl free radical, and superoxide free radical, and its IC50 is 0.2090 μg/mL, 15.020, and 1.217 mg/mL respectively. DOF can enhance the activities of T‐AOC, SOD, CAT, and GSH Px in the serum of aging mice, increase the content of GSH, and reduce the content of MDA when administered with DOF of 1.0, 2.0, and 4.0 g/kg for 6 weeks. In addition, it can enhance the activity of SOD in the skin of aging mice, increase the content of Hyp, and decrease the content of MDA, activated Keap1/Nrf2 pathway in the skin of aging mice. Applying DOF with a concentration of 0.2 g/mL on the face for 8 weeks can significantly improve the skin water score and elasticity value, reduce facial wrinkles, pores, acne, and UV spots, and improve the facial brown spots and roughness. Conclusion DOF can significantly improve skin aging caused by oxidative stress, and its mechanism may be related to scavenging free radicals in the body and improving skin quality.
ISSN:1473-2130
1473-2165
DOI:10.1111/jocd.16210