A Contrast‐Enhanced Tri‐Modal MRI Technique for High‐Performance Hypoxia Imaging of Breast Cancer

Personalized radiotherapy strategies enabled by the construction of hypoxia‐guided biological target volumes (BTVs) can overcome hypoxia‐induced radioresistance by delivering high‐dose radiotherapy to targeted hypoxic areas of the tumor. However, the construction of hypoxia‐guided BTVs is difficult...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-07, Vol.20 (28), p.e2308850-n/a
Main Authors: Mao, Quanliang, Gu, Mengyin, Hong, Chengyuan, Wang, Huiying, Ruan, Xinzhong, Liu, Zhusheng, Yuan, Bo, Xu, Mengting, Dong, Chen, Mou, Lei, Gao, Xiang, Tang, Guangyu, Chen, Tianxiang, Wu, Aiguo, Pan, Yuning
Format: Article
Language:English
Subjects:
biological target volume
Chemical synthesis
Hypoxia
hypoxia imaging
Magnetic resonance imaging
Mapping
Medical imaging
nanoprobe
Positron emission
Radiation dosage
Radiation therapy
radioresistance
tumor hypoxia
Tumors
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Summary:Personalized radiotherapy strategies enabled by the construction of hypoxia‐guided biological target volumes (BTVs) can overcome hypoxia‐induced radioresistance by delivering high‐dose radiotherapy to targeted hypoxic areas of the tumor. However, the construction of hypoxia‐guided BTVs is difficult owing to lack of precise visualization of hypoxic areas. This study synthesizes a hypoxia‐responsive T1, T2, T2 mapping tri‐modal MRI molecular nanoprobe (SPION@ND) and provides precise imaging of hypoxic tumor areas by utilizing the advantageous features of tri‐modal magnetic resonance imaging (MRI). SPION@ND exhibits hypoxia‐triggered dispersion‐aggregation structural transformation. Dispersed SPION@ND can be used for routine clinical BTV construction using T1‐contrast MRI. Conversely, aggregated SPION@ND can be used for tumor hypoxia imaging assessment using T2‐contrast MRI. Moreover, by introducing T2 mapping, this work designs a novel method (adjustable threshold‐based hypoxia assessment) for the precise assessment of tumor hypoxia confidence area and hypoxia level. Eventually this work successfully obtains hypoxia tumor target and accurates hypoxia tumor target, and achieves a one‐stop hypoxia‐guided BTV construction. Compared to the positron emission tomography‐based hypoxia assessment, SPION@ND provides a new method that allows safe and convenient imaging of hypoxic tumor areas in clinical settings. This article introduces a T1, T2, T2 mapping tri‐modal magnetic resonance imaging (MRI) molecular nanoprobe (SPION@ND) with hypoxia and acidic pH responsiveness, and demonstrates its capability in T1 contrast MRI, hypoxia T2 contrast MRI, and hypoxia T2 mapping imaging. The integration of molecular nanoprobe and tri‐modal MRI techniques explores a novel quantitative evaluation approach for tumor hypoxia.
ISSN:1613-6810
1613-6829
1613-6829
DOI:10.1002/smll.202308850