MCP‐5 suppresses osteoclast differentiation through Ccr5 upregulation

Human monocyte chemoattractant protein‐1 (MCP‐1) in mice has two orthologs, MCP‐1 and MCP‐5. MCP‐1, which is highly expressed in osteoclasts rather than in osteoclast precursor cells, is an important factor in osteoclast differentiation. However, the roles of MCP‐5 in osteoclasts are completely unkn...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular physiology 2024-02, Vol.239 (2), p.e31171-n/a
Main Authors: Kim, Jung Ha, Kim, Kabsun, Kim, Inyoung, Seong, Semun, Koh, Jeong‐Tae, Kim, Nacksung
Format: Article
Language:English
Subjects:
Animals
Bone loss
Bone mass
CC chemokine receptors
Ccr5
Cell Differentiation - physiology
Cells, Cultured
Differentiation
Down-regulation
Humans
JNK
Male
MCP‐5
Membrane Glycoproteins - metabolism
Mice
Mice, Inbred ICR
Monocyte chemoattractant protein
Monocyte Chemoattractant Proteins - genetics
Monocyte Chemoattractant Proteins - metabolism
Monocyte Chemoattractant Proteins - pharmacology
Monocytes
NF-kappa B - metabolism
NF‐κB
osteoclast
Osteoclastogenesis
Osteoclasts
Osteoclasts - cytology
Osteoclasts - metabolism
RANK Ligand - metabolism
RANK Ligand - pharmacology
Receptor Activator of Nuclear Factor-kappa B - metabolism
TRANCE protein
Transgenic mice
Up-Regulation
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human monocyte chemoattractant protein‐1 (MCP‐1) in mice has two orthologs, MCP‐1 and MCP‐5. MCP‐1, which is highly expressed in osteoclasts rather than in osteoclast precursor cells, is an important factor in osteoclast differentiation. However, the roles of MCP‐5 in osteoclasts are completely unknown. In this study, contrary to MCP‐1, MCP‐5 was downregulated during receptor activator of nuclear factor kappa B ligand (RANKL)‐induced osteoclast differentiation and was considered an inhibitory factor in osteoclast differentiation. The inhibitory role of MCP‐5 in osteoclast differentiation was closely related to the increase in Ccr5 expression and the inhibition of IκB degradation by RANKL. Transgenic mice expressing MCP‐5 controlled by Mx‐1 promoter exhibited an increased bone mass because of a decrease in osteoclasts. This result strongly supported that MCP‐5 negatively regulated osteoclast differentiation. MCP‐5 also prevented severe bone loss caused by RANKL.
ISSN:0021-9541
1097-4652
1097-4652
DOI:10.1002/jcp.31171