Cord blood platelet rich plasma (PRP) as a potential alternative to autologous PRP for allogenic preparation and regenerative applications

As an abundant supplier of growth factors, chemokines and other bioactive molecules, platelet rich plasma (PRP) become a leading therapy for tissue regeneration. The PRP therapy is an inexpensive and feasible source of growth factor compared to commercial products however, the better source of plate...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-03, Vol.262 (Pt 1), p.129850-129850, Article 129850
Main Authors: Mani, Rajesh, Roopmani, Purandhi, Rajendran, Jayakumar, Maharana, Sradhanjali, Giri, Jyotsnendu
Format: Article
Language:English
Subjects:
Adult blood
Allogeneic
Autologous
Blood Platelets - metabolism
Chemokines - metabolism
Fetal Blood
Immunomodulation
Intercellular Signaling Peptides and Proteins - metabolism
Platelet rich plasma
Platelet-Rich Plasma - metabolism
Regeneration
Umbilical cord blood
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Summary:As an abundant supplier of growth factors, chemokines and other bioactive molecules, platelet rich plasma (PRP) become a leading therapy for tissue regeneration. The PRP therapy is an inexpensive and feasible source of growth factor compared to commercial products however, the better source of platelets is the major challenge. Many researchers are skeptical about cord blood as an alternative source for the allogenic preparation of PRP. In the present study, we have compared adult peripheral and cord blood PRP for their regenerative capacity and immuno-modulatory nature. ELISA data indicates that the cord PRP contained a considerably higher amount of growth factors compared to adult PRP. In-vitro results indicate a significant increase in cell proliferation and migration with cord PRP treatment. The immunomodulatory evaluation shows cord blood PRP has better potential in switching activated macrophages to anti-inflammatory markers when compared with adult PRP, as well as the cytokines production indicates a significant reduction in the release of IFN-γ in cord PRP treatment. The study shows the beneficial effects of using cord blood PRP over adult PRP however, future studies are required to validate cord blood PRP as a permanent source for regenerative therapy.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2024.129850