The role of confined placental mosaicism in fetal growth restriction: A retrospective cohort study

Objective To evaluate which cytogenetic characteristics of confined placental mosaicism (CPM) detected in the first trimester chorionic villi and/or placentas in terms of chromosome aberration, cell lineage involved and trisomy origin will lead to fetal growth restriction and low birthweight. Method...

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Bibliographic Details
Published in:Prenatal diagnosis 2024-03, Vol.44 (3), p.289-296
Main Authors: Eggenhuizen, Geerke M., Go, Attie T. J. I., Sauter, Zoë, Hoffer, Mariëtte J. V., Haak, Monique C., Geeven, Geert, Diderich, Karin E. M., Joosten, Marieke, Born, Myrthe, Srebniak, Malgorzata I., Opstal, Diane
Format: Article
Language:English
Subjects:
Birth Weight
Cell lineage
Chromosome aberrations
Chromosomes, Human, Pair 16
Cohort analysis
Cohort Studies
Cytogenetics
Female
Fetal Growth Retardation - diagnosis
Fetal Growth Retardation - genetics
Fetal monitoring
Fetuses
Humans
Meiosis
Mosaicism
Placenta
Placenta - metabolism
Pregnancy
Retrospective Studies
Trisomy
Trisomy - diagnosis
Trisomy - genetics
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Summary:Objective To evaluate which cytogenetic characteristics of confined placental mosaicism (CPM) detected in the first trimester chorionic villi and/or placentas in terms of chromosome aberration, cell lineage involved and trisomy origin will lead to fetal growth restriction and low birthweight. Methods Cohort study using routinely collected perinatal data and cytogenetic data of non‐invasive prenatal testing, the first trimester chorionic villi sampling and postnatal placentas. Results 215 CPM cases were found. Fetal growth restriction (FGR) and low birthweight below the 10th percentile (BW 
ISSN:0197-3851
1097-0223
1097-0223
DOI:10.1002/pd.6533