High prevalence of low prognosis by the POSEIDON criteria in women undergoing planned oocyte cryopreservation

•Planned oocyte cryopreservation is being increasingly utilized worldwide.•Woman's age at cryopreservation and the number of mature oocytes thawed are the strongest predictors of live birth following oocyte warming.•A significant proportion of women cannot accumulate sufficient oocytes because...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2024-04, Vol.295, p.42-47
Main Authors: Horowitz, Eran, Mizrachi, Yossi, Barber, Elad, Shimshy, Miriam, Levitas-Djerbi, Talia, Finkelstein, Maya, Shalev, Amir, Farhi, Jacob, Raziel, Arieh, Esteves, Sandro C., Weissman, Ariel
Format: Article
Language:English
Subjects:
Cryopreservation
Female
Fertility preservation
Fertilization in Vitro
Follicle Stimulating Hormone
Gonadotropins
Humans
Oocytes
Ovulation Induction
Planned oocyte cryopreservation
Poor ovarian response
Poor prognosis
Poseidon
Prevalence
Prognosis
Retrospective Studies
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Summary:•Planned oocyte cryopreservation is being increasingly utilized worldwide.•Woman's age at cryopreservation and the number of mature oocytes thawed are the strongest predictors of live birth following oocyte warming.•A significant proportion of women cannot accumulate sufficient oocytes because of poor response to stimulation.•This novel, unexpected finding adds clinically relevant information for counselling and management of patients undergoing planned oocyte cryopreservation. Planned oocyte cryopreservation (OC) is being increasingly utilized worldwide. However, some women cannot accumulate sufficient oocytes because of poor response to stimulation. The POSEIDON classification is a novel system to classify patients with ‘expected’ or ‘unexpected’ inappropriate ovarian response to exogenous gonadotropins. Our study aimed to examine the prevalence of POSEIDON patients among women undergoing planned OC. We retrospectively reviewed the first cycles of 160 consecutive patients undergoing planned OC. Patients were classified into the four POSEIDON groups or as ‘non-POSEIDON’ based on age, AMH level and the number of oocytes retrieved. The primary outcome measure was the prevalence of POSEIDON patients. Overall, 63 patients (39.4 %) were classified as POSEIDON patients, 12 in group 1, 12 in group 2, 8 in group 3, and 31 in group 4. Compared to non-POSEIDON patients, POSEIDON patients had increased basal FSH levels and reduced serum AMH levels and antral follicle counts, required higher FSH starting doses and increased gonadotropin requirements and reached lower peak serum estradiol levels. Additionally, POSEIDON patients had a lower number of oocytes retrieved (7.6 ± 3.1 vs.20.2 ± 9.9, p 
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2024.01.025