Utility of the triglyceride-glucose index for predicting restenosis following revascularization surgery for extracranial carotid artery stenosis: A retrospective cohort study

•A retrospective cohort study of 2094 patients with ECAS.•The TYG index was used for the first time to predict restenosis after revascularization in patients with ECAS.•TYG index is closely related to vascular restenosis after carotid revascularization.•Although the surgical procedures are different...

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Published in:Journal of stroke and cerebrovascular diseases 2024-03, Vol.33 (3), p.107563-107563, Article 107563
Main Authors: Qu, Xiao-Peng, Wu, Ying-Le, Shen, Liang-Liang, Wang, Chao, Gao, Li, Ma, Jia-Qi, Qu, Yan, Liu, Bei
Format: Article
Language:English
Subjects:
Carotid artery stenting
Carotid endarterectomy
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - surgery
Constriction, Pathologic
Endarterectomy, Carotid - adverse effects
Extracranial carotid artery stenosis
Humans
Restenosis
Retrospective Studies
Risk Factors
Risk prediction
Stents
Treatment Outcome
Triglyceride-glucose index
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Summary:•A retrospective cohort study of 2094 patients with ECAS.•The TYG index was used for the first time to predict restenosis after revascularization in patients with ECAS.•TYG index is closely related to vascular restenosis after carotid revascularization.•Although the surgical procedures are different, with the increase of TYG index, the risk of postoperative vascular restenosis is significantly increased. Background: Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are effective interventions for treating extracranial carotid artery stenosis (ECAS), but long-term prognosis is limited by postoperative restenosis. Carotid restenosis is defined as carotid stenosis >50% by various examination methods in patients after carotid revascularization. This retrospective cohort study examined the value of the triglyceride-glucose (TyG) index for predicting vascular restenosis after carotid revascularization. Methods: A total of 830 patients receiving CEA (408 cases, 49.2%) or CAS (422 cases, 50.8%) were included in this study. Patients were stratified into three subgroups according to TyG index tertile (high, intermediate, and low), and predictive value for restenosis was evaluated by constructing multivariate Cox proportional hazard regression models. Results: Incidence of postoperative restenosis was significantly greater among patients with a high TyG index according to univariate analysis. Kaplan-Meier survival curve analysis revealed a progressive increase in restenosis prevalence with rising TyG index. Multivariate Cox regression models also identified TyG index as an independent predictor of restenosis, while receiver operating characteristic (ROC) curve analysis showed that TyG index predicted restenosis with moderate sensitivity (57.24%) and specificity (67.99%) (AUC: 0.619, 95% CI 0.585–0.652, z-statistic=4.745, p
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2024.107563