Synergistic anti-tumor effect of dual drug co-assembled nanoparticles based on ursolic acid and sorafenib

Both ursolic acid (UA) and sorafenib (Sora) have been generally utilized in cancer treatment, and the combination of the two has also shown a good anti-tumor effect. However, single-agent therapy for Hepatocellular carcinoma (HCC) has the disadvantages of multi-drug resistance, poor water solubility...

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Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2024-02, Vol.234, p.113724-113724, Article 113724
Main Authors: Tong, Ling-Wu, Le, Jing-Qing, Song, Xun-Huan, Li, Cheng-Lei, Yu, Shi-Jing, Lin, Ying-Qi, Tu, Yi-Fan, Shao, Jing-Wei
Format: Article
Language:English
Subjects:
Antineoplastic Agents
Carcinoma, Hepatocellular - pathology
Cell Line, Tumor
Co-assembly
Humans
Liver Neoplasms - pathology
Nanoparticles
Pharmaceutical Preparations
Sorafenib
Sorafenib - pharmacology
Sorafenib - therapeutic use
Synergistic therapy
Ursolic Acid
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Summary:Both ursolic acid (UA) and sorafenib (Sora) have been generally utilized in cancer treatment, and the combination of the two has also shown a good anti-tumor effect. However, single-agent therapy for Hepatocellular carcinoma (HCC) has the disadvantages of multi-drug resistance, poor water solubility and low bioavailability, and the application of traditional nanocarrier materials is limited due to their low drug loading and low carrier-related toxicity. Therefore, we prepared US NPs with different proportions of UA and Sora by solvent exchange method for achieving synergistic HCC therapy. US NPs had suitable particle size, good dispersibility and storage stability, which synergistically inhibited the proliferation of HepG2 cells, SMMC7721 cells and H22 cells. In addition, we also proved that US NPs were able to suppress the migration of HepG2 cells and SMMC7721 cells and reduce the adhesion ability and colony formation ability of these cells. According to the results, US NPs could degrade the membrane potential of mitochondrial, participate in cell apoptosis, and synergistically induce autophagy. Collectively, the carrier-free US NPs provide new strategies for HCC treatment and new ideas for the development of novel nano-drug delivery systems containing UA and Sora. •US NPs could suppress the migration, adhesion and formation of liver cancer cells.•US NPs could participate in cell apoptosis, and synergistically induce autophagy.•US NPs provide new ideas for novel nano-drug delivery containing UA and Sora.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2023.113724