Metal–Phenolic Networks‐Reinforced Extracellular Matrix Scaffold for Bone Regeneration via Combining Radical‐Scavenging and Photo‐Responsive Regulation of Microenvironment

The limited regulation strategies of the regeneration microenvironment significantly hinder bone defect repair effectiveness. One potential solution is using biomaterials capable of releasing bioactive ions and biomolecules. However, most existing biomaterials lack real‐time control features, failin...

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Bibliographic Details
Published in:Advanced healthcare materials 2024-06, Vol.13 (15), p.e2304158-n/a
Main Authors: Liu, Zhiqing, Wang, Tianlong, Zhang, Lei, Luo, Yiping, Zhao, Jinhui, Chen, Yixing, Wang, Yao, Cao, Wentao, Zhao, Xinyu, Lu, Bingqiang, Chen, Feng, Zhou, Zifei, Zheng, Longpo
Format: Article
Language:English
Subjects:
Angiogenesis
Biocompatibility
Biological activity
Biomedical materials
Biomimetic materials
Biomolecules
Bone biomaterials
Bone growth
Bone matrix
bone regeneration
Cell differentiation
Cell migration
Differentiation (biology)
Epigallocatechin gallate
Extracellular matrix
Free radicals
Hydroxyapatite
In vivo methods and tests
metal–phenolic networks
Microenvironments
Nanotechnology
Nanowires
Osteogenesis
Phenolic compounds
photothermal therapy
radical scavenging
Reactive oxygen species
Regeneration
Regeneration (physiology)
Scaffolds
Scavenging
Stem cells
Strontium
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Summary:The limited regulation strategies of the regeneration microenvironment significantly hinder bone defect repair effectiveness. One potential solution is using biomaterials capable of releasing bioactive ions and biomolecules. However, most existing biomaterials lack real‐time control features, failing to meet high regulation requirements. Herein, a new Strontium (Sr) and epigallocatechin‐3‐gallate (EGCG) based metal–phenolic network with polydopamine (PMPNs) modification is prepared. This material reinforces a biomimetic scaffold made of extracellular matrix (ECM) and hydroxyapatite nanowires (nHAW). The PMPNs@ECM/nHAW scaffold demonstrates exceptional scavenging of free radicals and reactive oxygen species (ROS), promoting HUVECs cell migration and angiogenesis, inducing stem cell osteogenic differentiation, and displaying high biocompatibility. Additionally, the PMPNs exhibit excellent photothermal properties, further enhancing the scaffold's bioactivities. In vivo studies confirm that PMPNs@ECM/nHAW with near‐infrared (NIR) stimulation significantly promotes angiogenesis and osteogenesis, effectively regulating the microenvironment and facilitating bone tissue repair. This research not only provides a biomimetic scaffold for bone regeneration but also introduces a novel strategy for designing advanced biomaterials. The combination of real‐time photothermal intervention and long‐term chemical intervention, achieved through the release of bioactive molecules/ions, represents a promising direction for future biomaterial development. Metal–phenolic network with polydopamine (PMPNs) modification endows the biomimetic scaffold made of extracellular matrix (ECM) and hydroxyapatite nanowires (nHAW) with the ability to scavenge free radical, reactive oxygen species (ROS), and photothermal properties. Furthermore, the enhanced release of Sr ions from PMPNs@ECM/nHAW scaffolds due to the responsiveness of PMPNs to ROS provides the biomimetic scaffold with much enhanced angiogenic and osteogenic properties.
ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.202304158