Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits

Gonadotropin-releasing hormone is implicated in cognitive functions, and its loss is a factor in pathological brain ageing. There are similarities between these processes and the neurological and cognitive deficits observed in patients with long COVID. Here, we explore the hypothesis that neuroanato...

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Bibliographic Details
Published in:Nature reviews. Endocrinology 2024-04, Vol.20 (4), p.189-190
Main Authors: Rasika, S, Nogueiras, Ruben, Schwaninger, Markus, Prevot, Vincent
Format: Article
Language:English
Subjects:
Aging
Anatomy
Animals
Biobanks
Brain architecture
Brain research
Cognition
Cognition & reasoning
Cognitive ability
Cognitive Dysfunction - etiology
COVID-19
Diabetes
Down syndrome
Endocrinology
Gene expression
Gonadotropin-releasing hormone
Gonadotropins
Homeostasis
Humans
Infections
Metabolism
Neurological diseases
Pandemics
Physiology
Pituitary (anterior)
Service Animals
Severe acute respiratory syndrome coronavirus 2
Transcriptomics
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Summary:Gonadotropin-releasing hormone is implicated in cognitive functions, and its loss is a factor in pathological brain ageing. There are similarities between these processes and the neurological and cognitive deficits observed in patients with long COVID. Here, we explore the hypothesis that neuroanatomical and transcriptomic alterations associated with long COVID could stem from this neuroendocrine perturbation.
ISSN:1759-5029
1759-5037
DOI:10.1038/s41574-024-00955-3