ZNF384 fusion transcript levels for measurable residual disease monitoring in adult B‐cell acute lymphoblastic leukemia

Zinc finger protein 384 (ZNF384) rearrangement defined a novel subtype of B‐cell acute lymphoblastic leukemia (B‐ALL). The prognostic significance of ZNF384 fusion transcript levels represented measurable residual disease remains to be explored. ZNF384 fusions were screened out in 57 adult B‐ALL pat...

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Bibliographic Details
Published in:Hematological oncology 2024-01, Vol.42 (1), p.e3251-n/a
Main Authors: Shi, Zong‐Yan, Wang, Xu, Chen, Wen‐Min, Li, Ling‐Di, Hao, Yue, Li, Jin‐Ying, Sun, Kai, Zhao, Xiao‐Su, Jiang, Hao, Jiang, Qian, Huang, Xiao‐Jun, Qin, Ya‐Zhen
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Adult
Allografts
B‐cell acute lymphoblastic leukemia
Chemotherapy
Consolidation
fusion genes
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Humans
Leukemia
Lymphatic leukemia
measurable residual disease
Neoplasm, Residual - diagnosis
Polymerase chain reaction
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Prognosis
Recurrence
Reduction
Remission
Stem cell transplantation
Stem cells
Survival
Trans-Activators - metabolism
Trans-Activators - therapeutic use
Transcription Factors
Zinc finger proteins
ZNF384
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Summary:Zinc finger protein 384 (ZNF384) rearrangement defined a novel subtype of B‐cell acute lymphoblastic leukemia (B‐ALL). The prognostic significance of ZNF384 fusion transcript levels represented measurable residual disease remains to be explored. ZNF384 fusions were screened out in 57 adult B‐ALL patients at diagnosis by real‐time quantitative polymerase chain reaction and their transcript levels were serially monitored during treatment. The reduction of ZNF384 fusion transcript levels at the time of achieving complete remission had no significant impact on survival, whereas its ≥2.5‐log reduction were significantly associated with higher relapse free survival (RFS) and overall survival (OS) rates after course 1 consolidation (p = 0.022 and = 0.0083) and course 2 consolidation (p = 0.0025 and = 0.0008). Compared with chemotherapy alone, allogeneic hematopoietic stem cell transplantation (allo‐HSCT) significantly improved RFS and OS of patients with
ISSN:0278-0232
1099-1069
DOI:10.1002/hon.3251