The influence of nutritional habits, body mass index and intestinal microbiota in mastocytosis on clinical symptoms using conventional culture and next generation sequencing

Background Mastocytosis is a rare neoplastic disease of the bone marrow associated with the proliferation and accumulation of mast cells in various internal organs, including the gastrointestinal tract. There are few studies describing the gut microbiome of patients with mastocytosis using next gene...

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Bibliographic Details
Published in:	Clinical and translational allergy 2024-01, Vol.14 (1), p.e12310-n/a
Main Authors:	Harcęko‐Zielińska, Ewelina, Niedoszytko, Marek, Górska, Aleksandra, Małgorzewicz, Sylwia, Gruchała‐Niedoszytko, Marta, Bronk, Marek, Dąbrowski, Slawomir, Chełminska, Marta, Jassem, Ewa
Format:	Article
Language:	eng
Subjects:	BMI eating disorders mastocytosis microbiome
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Summary:	Background Mastocytosis is a rare neoplastic disease of the bone marrow associated with the proliferation and accumulation of mast cells in various internal organs, including the gastrointestinal tract. There are few studies describing the gut microbiome of patients with mastocytosis using next generation sequencing supported using traditional culture methods. The aims of the study were, firstly, the determination of nutrition habits, composition of the intestinal microflora and BMI in mastocytosis, and secondly, analysis of mastocytosis severity and symptoms depending on the composition of the intestinal microflora. Methods The study included 47 patients with indolent systemic mastocytosis and 18 healthy controls. All participants gave their informed consent to participate in the study. The study consisted of 3 parts: I‐clinical assessment, II ‐ examination of the intestinal microflora using the biochemical method, III ‐ 16S rRNA sequencing. Results The nutrition habits and BMI of mastocytosis patients were similar to controls; however, most patients with mastocytosis had a low dietary vitamin and mineral content. As many as 94.5% of patients had too little fiber intake and mineral content. The most common cause of the abnormal stool test result with traditional culture was a titer of E. coli
ISSN:	2045-7022 2045-7022