Evolution of the Major Components of Innate Immunity in Animals

Innate immunity is present in all animals. In this review, we explore the main conserved mechanisms of recognition and innate immune responses among animals. In this sense, we discuss the receptors, critical for binding to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular...

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Bibliographic Details
Published in:Journal of molecular evolution 2024-02, Vol.92 (1), p.3-20
Main Authors: Silva, Rafael Cardoso Maciel Costa, Gomes, Fábio Mendonça
Format: Article
Language:English
Subjects:
Adaptive immunity
Allergens
Animal Genetics and Genomics
Animals
Arthropods
Biomedical and Life Sciences
Carrier Proteins
Cell Biology
Cytokines
Defense mechanisms
Evolution
Evolutionary Biology
Genomes
Immune response
Immune system
Immunity, Innate - genetics
Inflammation
Innate immunity
Invertebrates
Kinases
Life Sciences
Microbiology
Microorganisms
Pathogen-Associated Molecular Pattern Molecules
Pathogens
Phosphatase
Plant Genetics and Genomics
Plant Sciences
Proteins
Reactive oxygen species
Recognition
Review
Sensors
Transcription Factors
Vertebrates
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Summary:Innate immunity is present in all animals. In this review, we explore the main conserved mechanisms of recognition and innate immune responses among animals. In this sense, we discuss the receptors, critical for binding to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs); the downstream signaling proteins; and transcription factors that govern immune responses. We also highlight conserved inflammatory mediators that are induced after the recognition of DAMPs and PAMPs. At last, we discuss the mechanisms that are involved in the regulation and/or generation of reactive oxygen species (ROS), influencing immune responses, like heme-oxygenases (HOs).
ISSN:0022-2844
1432-1432
DOI:10.1007/s00239-024-10155-2