Risk factors for high-grade squamous intraepithelial lesions or cervical cancer in chronic inflammatory bowel disease

Chronic inflammatory bowel disease (IBD) is thought to increase the risk of high-grade histological intraepithelial lesions (HGIL) and cervical cancer. The risk factors for developing these lesions are poorly understood. This is a single-center retrospective case-control study including IBD patients...

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Published in:Gynécologie, obstétrique, fertilité & sénologie obstétrique, fertilité & sénologie, 2024-07, Vol.52 (7-8), p.460
Main Authors: Dujardin, Clémence, Balcaen, Thibault, Vanoost, Antoine, Chatelain, Denis, Gondry, Jean, Fumery, Mathurin, Foulon, Arthur
Format: Article
Language:fre
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Summary:Chronic inflammatory bowel disease (IBD) is thought to increase the risk of high-grade histological intraepithelial lesions (HGIL) and cervical cancer. The risk factors for developing these lesions are poorly understood. This is a single-center retrospective case-control study including IBD patients followed at our University Hospital Center from 2011 to 2021 who presented with HGIL or cervical cancer. Four controls were case-matched according to IBD type, age, active smoking and multiparity. Eighteen cases and 72 controls were included. We found no significant differences between the 2 groups with regard to mean age at IBD diagnosis, mean duration of IBD, IBD location, history of IBD-related surgery or even association with another chronic inflammatory disease. In our study, the use of immunosuppressants/biotherapies in these patients [50% (9/18) for cases vs. 56% (40/72) for controls; P=0.9] was not a risk factor for IGRA or cervical cancer. Similarly, neither the total duration of exposure to immunosuppressants/biotherapies (9.9±8years for cases vs. 6.6±5.3years for controls; P=0.1), nor combined therapies [11% (2/18) for cases vs. 6% (4/72) for controls; P=0.3], nor azathioprine or methotrexate use [22% (4/18) for cases vs. 11% (8/72) for controls; P=0.3] were found to be risk factors. In our study, we found no risk factors for patients with IBD to develop IGRA or cervical cancer.
ISSN:2468-7189
2468-7189
DOI:10.1016/j.gofs.2024.01.008