Multi-Scale FC-Based Multi-Order GCN: A Novel Model for Predicting Individual Behavior From fMRI

Predicting individual behavior from brain imaging data using machine learning is a rapidly growing field in neuroscience. Functional connectivity (FC), which captures interactions between different brain regions, contains valuable information about the organization of the brain and is considered a c...

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Bibliographic Details
Published in:IEEE transactions on neural systems and rehabilitation engineering 2024, Vol.32, p.548-558
Main Authors: Wen, Xuyun, Cao, Qumei, Jing, Bin, Zhang, Daoqiang
Format: Article
Language:English
Subjects:
Artificial neural networks
Behavioral sciences
Benchmarking
Brain
Brain - diagnostic imaging
Brain architecture
Brain mapping
Brain modeling
Classification
Correlation
Feature extraction
Functional connectivity
Functional magnetic resonance imaging
graph convolutional network
Healthy Volunteers
Human behavior
Humans
Intelligence
Machine learning
Magnetic Resonance Imaging
Message passing
multi-order
multi-scale
Neural networks
Neuroimaging
Organizations
Prediction models
Predictive models
Redundancy
Task analysis
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Summary:Predicting individual behavior from brain imaging data using machine learning is a rapidly growing field in neuroscience. Functional connectivity (FC), which captures interactions between different brain regions, contains valuable information about the organization of the brain and is considered a crucial feature for modeling human behavior. Graph convolutional networks (GCN) have proven to be a powerful tool for extracting graph structure features and have shown promising results in various FC-based classification tasks, such as disease classification and prognosis prediction. Despite this success, few behavior prediction models currently exist based on GCN, and their performance is not satisfactory. To address this gap, a new model called the Multi-Scale FC-based Multi-Order GCN (MSFC-MO-GCN) was proposed in this paper. The model considers the hierarchical structure of the brain system and utilizes FCs inferred from multiple spatial scales as input to comprehensively characterize individual brain organization. To enhance the feature learning ability of GCN, a multi-order graph convolutional layer is incorporated, which uses multi-order neighbors to guide message passing and learns high-order graph information of nodal connections. Additionally, an inter-subject contrast constraint is designed to control the potential information redundancy of FCs among different spatial scales during the feature learning process. Experimental evaluation were conducted on the publicly available dataset from human connectome project. A total of 805 healthy subjects were included and 5 representative behavior metrics were used. The experimental results show that our proposed method outperforms the existing behavior prediction models in all behavior prediction tasks.
ISSN:1534-4320
1558-0210
DOI:10.1109/TNSRE.2024.3357059